先天免疫和适应性免疫反应对动脉粥样硬化的影响。
The influence of innate and adaptive immune responses on atherosclerosis.
机构信息
Department of Medicine, University of California, San Diego, La Jolla, California 92093; email:
出版信息
Annu Rev Pathol. 2014;9:73-102. doi: 10.1146/annurev-pathol-020712-163936. Epub 2013 Aug 7.
Abstract
Both the chronic development of atherosclerotic lesions and the acute changes in lesion phenotype that lead to clinical cardiovascular events are significantly influenced by the innate and adaptive immune responses to lipoprotein deposition and oxidation in the arterial wall. The rapid pace of discovery of mechanisms of immunologic recognition, effector functions, and regulation has significantly influenced the study of atherosclerosis, and our new knowledge is beginning to affect how we treat this ubiquitous disease. In this review, we discuss recent advances in our understanding of how innate and adaptive immunity contribute to atherosclerosis, as well as therapeutic opportunities that arise from this knowledge.
摘要
动脉壁内脂蛋白沉积和氧化所引起的固有和适应性免疫反应，对动脉粥样硬化病变的慢性发展以及导致临床心血管事件的病变表型的急性变化，均有显著影响。免疫识别、效应功能和调节机制的发现速度非常快，这极大地推动了对动脉粥样硬化的研究，我们的新知识也开始影响我们对这种普遍疾病的治疗方式。在这篇综述中，我们讨论了目前对固有和适应性免疫如何促进动脉粥样硬化的理解方面的最新进展，以及由此产生的治疗机会。
相似文献
1
The influence of innate and adaptive immune responses on atherosclerosis.先天免疫和适应性免疫反应对动脉粥样硬化的影响。
Annu Rev Pathol. 2014;9:73-102. doi: 10.1146/annurev-pathol-020712-163936. Epub 2013 Aug 7.
2
Monocyte-Macrophages and T Cells in Atherosclerosis.动脉粥样硬化中的单核细胞-巨噬细胞与T细胞
Immunity. 2017 Oct 17;47(4):621-634. doi: 10.1016/j.immuni.2017.09.008.
3
Adaptive Response of T and B Cells in Atherosclerosis.动脉粥样硬化中 T 和 B 细胞的适应性反应。
Circ Res. 2016 Feb 19;118(4):668-78. doi: 10.1161/CIRCRESAHA.115.306427.
4
[Immune cells in atherosclerosis--good or bad?].[动脉粥样硬化中的免疫细胞——有益还是有害？]
Praxis (Bern 1994). 2016 Apr 13;105(8):437-44. doi: 10.1024/1661-8157/a002319.
5
Atherosclerosis antigens as targets for immunotherapy.动脉粥样硬化抗原作为免疫治疗的靶点。
Nat Cardiovasc Res. 2023 Dec;2(12):1129-1147. doi: 10.1038/s44161-023-00376-x. Epub 2023 Dec 11.
6
Update on cardiovascular disease in lupus.狼疮性心血管疾病的最新进展。
Curr Opin Rheumatol. 2016 Sep;28(5):468-76. doi: 10.1097/BOR.0000000000000307.
7
Atherosclerosis and immunity: A perspective.动脉粥样硬化与免疫：一个视角。
Trends Cardiovasc Med. 2019 Aug;29(6):363-371. doi: 10.1016/j.tcm.2018.09.017. Epub 2018 Sep 28.
8
Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies.动脉粥样硬化和心肌梗死中的体液免疫：从 B 细胞到抗体。
Cardiovasc Res. 2021 Nov 22;117(13):2544-2562. doi: 10.1093/cvr/cvab285.
9
Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives.炎症小体、T 淋巴细胞与固有免疫-适应性免疫相互作用：在心血管疾病中的作用及治疗前景。
Thromb Haemost. 2018 Aug;118(8):1352-1369. doi: 10.1055/s-0038-1666860. Epub 2018 Jul 10.
10
Lipid-driven immunometabolic responses in atherosclerosis.脂代谢驱动的动脉粥样硬化中的免疫代谢反应。
Curr Opin Lipidol. 2018 Oct;29(5):375-380. doi: 10.1097/MOL.0000000000000540.
引用本文的文献
1
The role of immune checkpoints PD-1 and CTLA-4 in cardiovascular complications leading to heart failure.免疫检查点蛋白PD-1和CTLA-4在导致心力衰竭的心血管并发症中的作用。
Front Immunol. 2025 Apr 4;16:1561968. doi: 10.3389/fimmu.2025.1561968. eCollection 2025.
2
Interaction between lipid metabolism and macrophage polarization in atherosclerosis.动脉粥样硬化中脂质代谢与巨噬细胞极化之间的相互作用。
iScience. 2025 Mar 7;28(4):112168. doi: 10.1016/j.isci.2025.112168. eCollection 2025 Apr 18.
3
Lupus nephritis as an independent risk factor for carotid atherosclerosis in patients with systemic lupus erythematosus.狼疮性肾炎是系统性红斑狼疮患者颈动脉粥样硬化的独立危险因素。
Clin Rheumatol. 2025 May;44(5):1927-1937. doi: 10.1007/s10067-025-07413-z. Epub 2025 Mar 26.
4
Association of the systemic immune-inflammation index with clinical outcomes in acute myocardial infarction patients with hypertension.系统性免疫炎症指数与合并高血压的急性心肌梗死患者临床结局的关联
BMC Immunol. 2025 Feb 28;26(1):10. doi: 10.1186/s12865-025-00690-y.
5
The Anti-Inflammatory Potential of Tricyclic Antidepressants (TCAs): A Novel Therapeutic Approach to Atherosclerosis Pathophysiology.三环类抗抑郁药（TCAs）的抗炎潜力：一种针对动脉粥样硬化病理生理学的新型治疗方法。
Pharmaceuticals (Basel). 2025 Jan 31;18(2):197. doi: 10.3390/ph18020197.
6
Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV database.冠心病监护病房中急性心肌梗死患者炎症标志物对全因死亡率的预后价值：一项基于MIMIC-IV数据库的回顾性研究
Front Cardiovasc Med. 2025 Jan 22;12:1439650. doi: 10.3389/fcvm.2025.1439650. eCollection 2025.
7
Integrative single-cell and bulk RNA-seq analyses identify CD4 T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque.整合单细胞和批量RNA测序分析确定了参与介导动脉粥样硬化斑块进展的CD4 T细胞亚群浸润和调节性T细胞生物标志物。
Front Immunol. 2025 Jan 17;15:1528475. doi: 10.3389/fimmu.2024.1528475. eCollection 2024.
8
Macrophage-based pathogenesis and theranostics of vulnerable plaques.基于巨噬细胞的易损斑块发病机制与诊疗学
Theranostics. 2025 Jan 2;15(4):1570-1588. doi: 10.7150/thno.105256. eCollection 2025.
9
Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans.人体血浆中抗磷酸胆碱IgM抗体水平与骨矿物质密度呈负相关。
Sci Rep. 2025 Jan 15;15(1):2109. doi: 10.1038/s41598-025-85624-9.
10
Identification of macrophage differentiation related genes and subtypes linking atherosclerosis plaque processing and metabolic syndrome via integrated bulk and single-cell sequence analysis.通过整合批量和单细胞序列分析鉴定与巨噬细胞分化相关的基因及亚型，这些基因及亚型与动脉粥样硬化斑块形成过程和代谢综合征相关。
Heliyon. 2024 Jul 11;10(14):e34295. doi: 10.1016/j.heliyon.2024.e34295. eCollection 2024 Jul 30.
本文引用的文献
1
Cytotoxic and proinflammatory CD8+ T lymphocytes promote development of vulnerable atherosclerotic plaques in apoE-deficient mice.细胞毒性和促炎 CD8+T 淋巴细胞促进载脂蛋白 E 缺陷小鼠易损粥样斑块的发展。
Circulation. 2013 Mar 5;127(9):1028-39. doi: 10.1161/CIRCULATIONAHA.112.001347. Epub 2013 Feb 8.
2
T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development.CD28-CD80/86 与 CTLA-4 对 T 细胞的共刺激及其负调控因子强烈影响动脉粥样硬化的加速发展。
Int J Cardiol. 2013 Oct 3;168(3):1965-74. doi: 10.1016/j.ijcard.2012.12.085. Epub 2013 Jan 23.
3
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.不变自然杀伤 T 细胞：与多种效应功能相关的先天激活方案。
Nat Rev Immunol. 2013 Feb;13(2):101-17. doi: 10.1038/nri3369. Epub 2013 Jan 21.
4
Adaptive immunity in atherogenesis: new insights and therapeutic approaches.动脉粥样硬化形成中的适应性免疫：新的见解和治疗方法。
J Clin Invest. 2013 Jan;123(1):27-36. doi: 10.1172/JCI63108. Epub 2013 Jan 2.
5
Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs.调节性 T 细胞介导的动脉粥样硬化抑制需要树突状细胞中的 MYD88 信号传导。
J Clin Invest. 2013 Jan;123(1):179-88. doi: 10.1172/JCI64617. Epub 2012 Dec 21.
6
Moving beyond JUPITER: will inhibiting inflammation reduce vascular event rates?超越 JUPITER：抑制炎症能否降低血管事件发生率？
Curr Atheroscler Rep. 2013 Jan;15(1):295. doi: 10.1007/s11883-012-0295-3.
7
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.辅助性 T 细胞 17 通路与肠道、肺部和皮肤的炎症性疾病。
Annu Rev Pathol. 2013 Jan 24;8:477-512. doi: 10.1146/annurev-pathol-011110-130318. Epub 2012 Nov 15.
8
Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events.氧化特异性生物标志物与 15 年心血管和卒中结局及心血管事件的净重新分类：前瞻性研究
J Am Coll Cardiol. 2012 Nov 20;60(21):2218-29. doi: 10.1016/j.jacc.2012.08.979. Epub 2012 Nov 1.
9
CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-/-) mice.CTLA4-IgG 通过抑制 apoE(-/-) 小鼠 T 细胞过度激活来改善同型半胱氨酸加速的动脉粥样硬化。
Cardiovasc Res. 2013 Feb 1;97(2):349-59. doi: 10.1093/cvr/cvs330. Epub 2012 Oct 31.
10
Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus.类风湿关节炎和狼疮中早发动脉粥样硬化的机制。
Annu Rev Med. 2013;64:249-63. doi: 10.1146/annurev-med-060911-090007. Epub 2012 Sep 27.
Zotero 插件