[糖尿病肾病相关因素分析]
[Analyses on the relative factors regarding diabetic nephropathy].
作者信息
Shao Hai-lin, Song Chun-qing, Xu Dong-hong, Shang Xiao-jing, Hao Zhao-hu
机构信息
Department of Endocrinology of Tianjin Fourth Central Hospital, Tianjin 300140, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2013 Apr;34(4):393-5.
OBJECTIVE
To analyze the related factors regarding diabetic nephropathy (DN).
METHODS
A total number of 756 diabetic patients from 2009 to 2011 were analyzed retrospectively. Three groups were formed according to the urinary albumin excretion rates (UAER). Patients with UAER < 20 µg/min was grouped to group A, with UAER from 20 to 200 µg/min as group B, and the others with UAER ≥ 200 µg/min was grouped to group C. General characteristics and laboratory parameters were then compared and related factors of DN analyzed.
RESULTS
The constituent ratio of nephropathy was 30.2% (228/756). Patient's age, duration of disease, both diastolic and systolic blood pressure of group A were significantly higher than the non-DN group (A) (P < 0.05). Patient's age, disease duration, both diastolic and systolic blood pressure of group C were (64.08 ± 11.71) years, (14.67 ± 7.34) years, (87.43 ± 14.36) mm Hg, (152.45 ± 18.48) mm Hg, respectively, with statistically significant difference (P < 0.05) between group C and group B. FPG, TG, TC, HDL-C, UA, HbA1c, FINS, FCP of group B were (9.27 ± 3.06) mmol/L, (1.98 ± 0.37) mmol/L, (5.01 ± 1.08) mmol/L, (1.05 ± 0.35) mmol/L, (312.78 ± 39.83) mmol/L, (9.33 ± 1.47)%, (11.45 ± 7.83) µU/ml, (509.73 ± 132.78) pmol/L respectively, with significant difference (P < 0.05) between group B and group A. FPG, TG, HDL-C, UA, FINS, FCP of group C were (9.29 ± 3.12) mmol/L, (2.02 ± 0.36) mmol/L, (1.04 ± 0.27) mmol/L, (389.72 ± 46.32) mmol/L, (11.09 ± 8.29) µU/ml, (575.77 ± 143.29) pmol/L respectively, with significant difference (P < 0.05) between group C and group A. UA, FINS, FCP were found with significant differences (P < 0.05) between group C and group B. Data from multivariate logistic regression showed that DNs were related with disease duration, BMI, systolic blood pressure, HbAlc, FPG, UA.
CONCLUSION
DN was closely related to the duration, age, blood sugar, blood lipids, blood pressure, uric acid levels of the disease.
目的
分析糖尿病肾病（DN）的相关因素。
方法
回顾性分析2009年至2011年共756例糖尿病患者。根据尿白蛋白排泄率（UAER）分为三组。UAER＜20μg/min者为A组，UAER为20～200μg/min者为B组，UAER≥200μg/min者为C组。然后比较一般特征和实验室参数，并分析DN的相关因素。
结果
肾病构成比为30.2%（228/756）。A组患者的年龄、病程、舒张压和收缩压均显著高于非糖尿病肾病组（A组）（P＜0.05）。C组患者的年龄、病程、舒张压和收缩压分别为（64.08±11.71）岁、（14.67±7.34）年、（87.43±14.36）mmHg、（152.45±18.48）mmHg，C组与B组比较差异有统计学意义（P＜0.05）。B组的空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、空腹C肽（FCP）分别为（9.27±3.06）mmol/L、（1.98±0.37）mmol/L、（5.01±1.08）mmol/L、（1.05±0.35）mmol/L、（312.78±39.83）mmol/L、（9.33±1.47）%、（11.45±7.83）μU/ml、（509.73±132.78）pmol/L，B组与A组比较差异有统计学意义（P＜0.05）。C组的FPG、TG、HDL-C、UA、FINS、FCP分别为（9.29±3.12）mmol/L、（2.02±0.36）mmol/L、（1.04±0.27）mmol/L、（389.72±46.32）mmol/L、（11.09±8.29）μU/ml、（575.77±143.29）pmol/L，C组与A组比较差异有统计学意义（P＜0.05）。C组与B组比较，UA、FINS、FCP差异有统计学意义（P＜0.05）。多因素logistic回归分析显示，糖尿病肾病与病程、体重指数、收缩压、糖化血红蛋白、空腹血糖、尿酸有关。
结论
糖尿病肾病与病程、年龄、血糖、血脂、血压、尿酸水平密切相关。
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