2型糖尿病患者糖尿病视网膜病变的危险因素

Risk factors of diabetic retinopathy in type 2 diabetic patients.

作者信息

Cai Xiao-ling, Wang Fang, Ji Li-nong

机构信息

Department of Endocrine and Metabolism, Peking University People's Hospital, Beijing 100044, China.

出版信息

Chin Med J (Engl). 2006 May 20;119(10):822-6.

PMID:16732984

Abstract

BACKGROUND

Advances in treatment have greatly reduced the risk of blindness from this disease, but because diabetes is so common, diabetic retinopathy remains an important problem. The purpose of this study is to investigate the risk factors of diabetic retinopathy (DR) in Chinese type 2 diabetic patients.

METHODS

Totally 746 type 2 diabetic patients were selected for biochemical and clinical characteristics test and examined by the retina-camera for diabetic retinopathy and the average age was 55.9 years old.

RESULTS

A total of 526 patients was classified as non-DR, 159 patients as non-proliferative-DR and 61 patients as proliferative-DR. Duration of diabetes [(66.09 +/- 72.51) months vs (143.71 +/- 93.27) months vs (174.30 +/- 81.91) months, P = 0.00], systolic blood pressure [(131.95 +/- 47.20) mmHg vs (138.71 +/- 21.36) mmHg vs (147.58 +/- 24.10) mmHg, P = 0.01], urine albumin [(32.79 +/- 122.29) mg/L vs (190.96 +/- 455.65) mg/L vs (362.00 +/- 552.51) mg/L, P = 0.00], glycated hemoglobin (HbA1c) [(8.68 +/- 2.26)% vs (9.42 +/- 1.84)% vs (9.42 +/- 1.96)%, P = 0.04], C-reactive protein (CRP) [(3.19 +/- 7.37) mg/L vs (6.36 +/- 23.59) mg/L vs (3.02 +/- 4.34) mg/L, P = 0.03], high-density lipoprotein cholesterol (HDL-C) [(1.23 +/- 0.37) mmol/L vs (1.33 +/- 0.35) mmol/L vs (1.24 +/- 0.33) mmol/L, P = 0.01], uric acid (UA) [(288.51 +/- 90.85) mmol/L vs (300.29 +/- 101.98) mmol/L vs (337.57 +/- 115.09) mmol/L, P = 0.00], creatinine (CREA) [(84.22 +/- 16.31) micromol/L vs (89.35 +/- 27.45) micromol/L vs (103.28 +/- 48.64) micromol/L, P = 0.00], blood urine nitrogen (BUN) [(5.62 +/- 1.62) mmol/L vs (6.55 +/- 2.74) mmol/L vs (8.11 +/- 3.60) mmol/L, P = 0.00] were statistically different among the three groups. Logistic regression analysis showed that diabetic duration and urine albumin were two independent risk factors of DR (the OR values were 1.010 and 1.003 respectively).

CONCLUSIONS

Diabetic duration and urine albumin are two independent risk factors of diabetic retinopathy in elderly type 2 diabetic patients.

摘要

背景

治疗方面的进展已大幅降低了这种疾病导致失明的风险，但由于糖尿病极为常见，糖尿病视网膜病变仍是一个重要问题。本研究的目的是调查中国2型糖尿病患者发生糖尿病视网膜病变（DR）的危险因素。

方法

共选取746例2型糖尿病患者进行生化和临床特征检测，并使用视网膜相机检查糖尿病视网膜病变情况，平均年龄为55.9岁。

结果

共有526例患者被归类为非糖尿病视网膜病变，159例为非增殖性糖尿病视网膜病变，61例为增殖性糖尿病视网膜病变。糖尿病病程[（66.09±72.51）个月 vs （143.71±93.27）个月 vs （174.30±81.91）个月，P = 0.00]、收缩压[（131.95±47.20）mmHg vs （138.71±21.36）mmHg vs （147.58±24.10）mmHg，P = 0.01]、尿白蛋白[（32.79±122.29）mg/L vs （190.96±455.65）mg/L vs （362.00±552.51）mg/L，P = 0.00]、糖化血红蛋白（HbA1c）[（8.68±2.26）% vs （9.42±1.84）% vs （9.42±1.96）%，P = 0.04]、C反应蛋白（CRP）[（3.19±7.37）mg/L vs （6.36±23.59）mg/L vs （3.02±4.34）mg/L，P = 0.03]、高密度脂蛋白胆固醇（HDL-C）[（1.23±0.37）mmol/L vs （1.33±0.35）mmol/L vs （1.24±0.33）mmol/L，P = 0.01]、尿酸（UA）[（288.51±90.85）mmol/L vs （300.29±101.98）mmol/L vs （337.57±115.09）mmol/L，P = 0.