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美沙酮维持治疗对 HIV/AIDS 吸毒者健康效用、卫生保健利用和支出的影响。

Impact of methadone maintenance on health utility, health care utilization and expenditure in drug users with HIV/AIDS.

机构信息

Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Viet Nam; School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

Authority of HIV/AIDS Control, Ministry of Health, Hanoi, Viet Nam.

出版信息

Int J Drug Policy. 2013 Nov;24(6):e105-10. doi: 10.1016/j.drugpo.2013.07.007. Epub 2013 Aug 9.

Abstract

BACKGROUND

This study assessed the impact of methadone maintenance treatment (MMT) on health utility, health care service utilization, and out-of-pocket (OOP) health expenditure in drug users with HIV/AIDS in Vietnam.

METHODS

Using the 2012 Vietnam HIV Service Users Survey data, a post-evaluation was designed to compare 121 MMT patients with 347 non-MMT patients who were matched using propensity scores of MMT covariates. Health utility was measured using the EuroQOL - five dimensions - five levels (EQ-5D-5L) and a visual analogue scale (EQ-VAS).

RESULTS

The mean EQ-5D-5L single index and EQ-VAS score of MMT patients were 0.68 (95% CI=0.64-0.73) and 71.5% (95% CI=68.2-74.9). Compared with the control group, the adjusted differences in health utility were 0.08 and 4.43% (p=0.07), equivalent to 12.1% and 6.5% increases during MMT. There was a 45.9% decrease in the frequency of health care service utilization that was attributable to MMT. Although, antiretroviral treatment and MMT services were free-of-charge, MMT and non-MMT patients still paid their OOP for health care for averagely US$ 16.3/month and US$ 28.9/month. The adjusted difference between the two groups was US$ 19.3/month ($ 231.6/year) that equivalents to a reduction of 66.7% in OOP health expenditure related to MMT.

CONCLUSION

MMT was associated with a clinically important difference in health utility, large reductions in health care service utilization and OOP health expenditure in HIV-positive drug users. Scaling up MMT in large drug-using population could help improve the outcomes of HIV/AIDS interventions and reduce economic vulnerability of affected households.

摘要

背景

本研究评估了美沙酮维持治疗(MMT)对越南 HIV/AIDS 吸毒者的健康效用、医疗服务利用和自付医疗支出的影响。

方法

使用 2012 年越南 HIV 服务使用者调查数据,采用倾向评分匹配 MMT 协变量后,进行了一项事后评估,将 121 名 MMT 患者与 347 名非 MMT 患者进行比较。健康效用采用欧洲五维健康量表(EQ-5D-5L)和视觉模拟量表(EQ-VAS)进行测量。

结果

MMT 患者的平均 EQ-5D-5L 单指数和 EQ-VAS 评分分别为 0.68(95%置信区间 0.64-0.73)和 71.5%(95%置信区间 68.2-74.9)。与对照组相比,健康效用的调整差异为 0.08 和 4.43%(p=0.07),相当于 MMT 期间健康状况改善了 12.1%和 6.5%。由于 MMT,医疗服务利用的频率降低了 45.9%。尽管抗逆转录病毒治疗和 MMT 服务是免费的,但 MMT 和非 MMT 患者仍需自付医疗费用,平均每月分别为 16.3 美元和 28.9 美元。两组之间的调整差异为 19.3 美元/月(231.6 美元/年),相当于与 MMT 相关的自付医疗支出减少了 66.7%。

结论

MMT 与 HIV 阳性吸毒者的健康效用、医疗服务利用和自付医疗支出大幅减少有关。在较大的吸毒人群中扩大 MMT 规模有助于改善 HIV/AIDS 干预措施的效果,并减轻受影响家庭的经济脆弱性。

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