Department of Hematology, Ruijin Hospital, Shanghai Institute of Hematology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Leuk Res. 2013 Oct;37(10):1216-21. doi: 10.1016/j.leukres.2013.07.020. Epub 2013 Aug 12.
We presented our experience in chronic myeloid leukemia (CML) patients who conceived children and/or became pregnant while receiving tyrosine kinase inhibitor (TKI). Among 7 male patients, 7 pregnancies resulted in the birth of 7 healthy babies. Among 18 female patients, 8 ended in elective abortion; 3 had spontaneous abortion, and 7 carried to term, resulting in the birth of 8 healthy babies. All children have normal growth and development. All patients remain in TKI therapy and in good response. It is suggested that female patients are advised to practice adequate contraception. No special precautions apply for male patients receiving TKI.
我们介绍了在接受酪氨酸激酶抑制剂（TKI）治疗期间怀孕和/或生育的慢性髓性白血病（CML）患者的经验。7 名男性患者中，7 次妊娠均产下 7 名健康婴儿。18 名女性患者中，8 人选择人工流产；3 人自然流产；7 人妊娠至足月，产下 8 名健康婴儿。所有孩子均正常生长发育。所有患者均继续 TKI 治疗，疗效良好。建议女性患者采取充分的避孕措施。接受 TKI 治疗的男性患者无需特殊注意。
