Cengiz Seval Güldane, Özkavukçu Sinan, Seval Murat, Aylı Meltem
Ufuk University Faculty of Medicine, Department of Hematology, Ankara, Turkey E-mail:
Turk J Haematol. 2017 Jun 5;34(2):137-142. doi: 10.4274/tjh.2016.0092. Epub 2016 Jul 28.
Tyrosine kinase inhibitors may have deleterious effects on spermatogenesis or folliculogenesis, resulting in male or female subfertility. The aim of this study is to determine the effect of nilotinib, which is used routinely to treat chronic myeloid leukemia, on spermatogenesis and folliculogenesis by using histopathological parameters.
Ten male and ten female mice were orally treated with nilotinib at 20 mg/kg body weight dissolved in drinking water daily for 2 months.
When compared with the control group, a statistically significant decrease was demonstrated in the total follicle numbers of the female mice in the nilotinib group (268±110 vs. 170±60; p=0.03). Active spermatogenesis was observed in each tubule sample taken from the mice in the control and nilotinib groups. Spermatogenic activity was similar in the two groups.
We have demonstrated that even though spermatogenesis is preserved, folliculogenesis is inhibited by the usage of a continuous nilotinib treatment dose in chronic myeloid leukemia.
酪氨酸激酶抑制剂可能对精子发生或卵泡发生产生有害影响，导致男性或女性生育力低下。本研究的目的是通过组织病理学参数来确定常用于治疗慢性髓性白血病的尼罗替尼对精子发生和卵泡发生的影响。
将20只雄性和20只雌性小鼠，每日经口给予溶解于饮用水中的尼罗替尼，剂量为20mg/kg体重，持续2个月。
与对照组相比，尼罗替尼组雌性小鼠的卵泡总数有统计学意义的显著减少（268±110对170±60；p=0.03）。在从对照组和尼罗替尼组小鼠采集的每个小管样本中均观察到活跃的精子发生。两组的精子发生活性相似。
我们已经证明，在慢性髓性白血病中，即使精子发生得以保留，但持续使用尼罗替尼治疗剂量会抑制卵泡发生。
