Howland Robert H
J Psychosoc Nurs Ment Health Serv. 2013 Sep;51(9):13-6. doi: 10.3928/02793695-20130805-01. Epub 2013 Aug 16.
Metformin, currently approved for the treatment of type 2 diabetes, is an interesting drug that has various cellular and molecular mechanisms. These mechanisms have justified other off-label clinical and investigational uses for diabetes prevention in high-risk patients, for polycystic ovary syndrome, non-diabetic obesity, non-alcoholic fatty liver disease, and for prevention or treatment of cancer. A large number of controlled and uncontrolled studies have generally found metformin to be effective, well tolerated, and safe for preventing or treating antipsychotic-related weight gain and for improving metabolic abnormalities in psychiatric patient populations. Metformin has the potential effect of inducing hippocampal neurogenesis, and additional studies of this drug are warranted in patients with mood or cognitive disorders.
二甲双胍目前被批准用于治疗2型糖尿病，是一种具有多种细胞和分子机制的有趣药物。这些机制为其在高危患者预防糖尿病、多囊卵巢综合征、非糖尿病性肥胖、非酒精性脂肪性肝病以及预防或治疗癌症等其他未获批的临床和研究用途提供了依据。大量对照和非对照研究普遍发现，二甲双胍在预防或治疗抗精神病药物相关体重增加以及改善精神疾病患者群体的代谢异常方面有效、耐受性良好且安全。二甲双胍具有诱导海马神经发生的潜在作用，因此有必要对患有情绪或认知障碍的患者进行该药物的进一步研究。
