Virginia Commonwealth University, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology , Richmond, VA , USA.
Expert Opin Investig Drugs. 2013 Dec;22(12):1511-7. doi: 10.1517/13543784.2013.833604. Epub 2013 Aug 26.
Metformin is the most commonly prescribed antidiabetic oral agent. It has also been used off-label for polycystic ovarian syndrome, steatohepatitis, and HIV-associated metabolic abnormalities. However, this oldie is a newbie for the oncologist. Population studies have suggested that metformin decreased the incidence and mortality rates of cancer in diabetic patients. With better understanding of its mechanisms of antitumor activity, metformin may become a new drug for cancer in combination with chemotherapy or targeted therapy.
二甲双胍是最常用的抗糖尿病口服药物。它也被用于治疗多囊卵巢综合征、脂肪性肝炎和 HIV 相关代谢异常等适应证外的疾病。然而，对于肿瘤学家来说，这种老药却是新药。人群研究表明，二甲双胍降低了糖尿病患者的癌症发病率和死亡率。随着对其抗肿瘤活性机制的更好理解，二甲双胍可能与化疗或靶向治疗联合成为一种新的癌症治疗药物。
