Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160 C, 4089100, Concepcion, Chile.
J Hematol Oncol. 2013 Aug 13;6:57. doi: 10.1186/1756-8722-6-57.
Acute myeloid leukemia (AML) is a rather common disease, characterized by the presence of a clonal population of hematopoietic progenitor cells with impaired differentiation. Although traditionally AML has been considered the result of genetic alterations, more recently experimental evidence have demonstrated that epigenetic modifications are important in development and maintenance of leukemia cells. In this review we summarize current scientific knowledge of epigenetic alterations involved in leukemogenesis. We also highlight the developing of new technological strategies that are based on epigenetic processes and have been registered as Patents of Inventions in the United Nations dependent World Intellectual Property Office (WIPO) and the main Patent offices worldwide.
急性髓系白血病（AML）是一种较为常见的疾病，其特征是存在具有分化障碍的造血祖细胞的克隆群体。尽管传统上 AML 被认为是遗传改变的结果，但最近的实验证据表明，表观遗传修饰在白血病细胞的发育和维持中起着重要作用。在这篇综述中，我们总结了参与白血病发生的表观遗传改变的现有科学知识。我们还强调了正在开发的新的基于表观遗传过程的技术策略，这些策略已在联合国下属的世界知识产权组织（WIPO）和世界主要专利局注册为发明专利。
