Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncologist. 2013;18(5):619-24. doi: 10.1634/theoncologist.2012-0465. Epub 2013 May 13.
The introduction of the hypomethylating agents azacitidine and decitabine has been a major advancement in the treatment of patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia who are ineligible for more intensive treatments. This concise drug review summarizes the current state of treatment with azacitidine and decitabine.
低甲基化药物阿扎胞苷和地西他滨的引入是治疗不适合更强化疗的高危骨髓增生异常综合征、慢性粒单核细胞白血病和急性髓系白血病患者的重大进展。本简明药物综述总结了阿扎胞苷和地西他滨的治疗现状。