简明药物评论：阿扎胞苷和地西他滨。
Concise drug review: azacitidine and decitabine.
机构信息
Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands.
出版信息
Oncologist. 2013;18(5):619-24. doi: 10.1634/theoncologist.2012-0465. Epub 2013 May 13.
Abstract
The introduction of the hypomethylating agents azacitidine and decitabine has been a major advancement in the treatment of patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia who are ineligible for more intensive treatments. This concise drug review summarizes the current state of treatment with azacitidine and decitabine.
摘要
低甲基化药物阿扎胞苷和地西他滨的引入是治疗不适合更强化疗的高危骨髓增生异常综合征、慢性粒单核细胞白血病和急性髓系白血病患者的重大进展。本简明药物综述总结了阿扎胞苷和地西他滨的治疗现状。
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Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes.来那度胺和阿扎胞苷联合治疗高危骨髓增生异常综合征患者的 2 期研究。
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Platelet doubling after the first azacitidine cycle is a promising predictor for response in myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML) patients in the Dutch azacitidine compassionate named patient programme.在荷兰阿扎胞苷同情用药计划中，第一个阿扎胞苷周期后血小板倍增是骨髓增生异常综合征（MDS）、慢性粒单核细胞白血病（CMML）和急性髓系白血病（AML）患者反应的有希望的预测指标。
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