Department of Obstetrics & Gynecology (791), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.
Hum Pathol. 2013 Oct;44(10):2293-301. doi: 10.1016/j.humpath.2013.05.011. Epub 2013 Aug 9.
Knowledge on the nature of the endometrium in women without symptoms of endometrial disease is poor. Therefore, the aim of this prospective study was to describe the endometrium of a cohort of asymptomatic women. The entire endometrium of premenopausal and postmenopausal women was embedded for histologic examination. All included patients underwent a hysterectomy on indication of uterovaginal prolapse, from July 2011 to October 2012, in 3 hospitals in the South of the Netherlands. Exclusion criteria were symptoms of postmenopausal vaginal blood loss or premenopausal disordered vaginal bleeding. As a result, 68 women were included in the study, 48 women were postmenopausal and 20 were premenopausal. In the endometrium of 10 women, simple hyperplasia was found (15%); 1, complex hyperplasia (2%); 2, simple atypical hyperplasia (3%); 2, complex atypical hyperplasia (3%); and 2, a small focus of intramucosal endometrioid endometrial carcinoma (3%). In general, the endometrium was heterogeneous, and most lesions were not present in the entire endometrium. In conclusion, after examining the entire endometrium, a remarkable high prevalence of endometrial pathology was found in asymptomatic women. The clinical meaning of these lesions is not yet clear, but endometrial pathology may frequently exist without symptoms.
关于无症状子宫内膜疾病女性子宫内膜性质的知识了解甚少。因此，本前瞻性研究旨在描述一组无症状女性的子宫内膜情况。对绝经前和绝经后妇女的整个子宫内膜进行组织学检查。所有纳入的患者均因子宫阴道脱垂的指征于 2011 年 7 月至 2012 年 10 月在荷兰南部的 3 家医院接受了子宫切除术。排除标准为绝经后阴道出血或绝经前不规则阴道出血的症状。结果，共有 68 名女性入组研究，其中 48 名处于绝经后，20 名处于绝经前。在 10 名女性的子宫内膜中发现单纯性增生（15%）；1 例复杂性增生（2%）；2 例单纯性不典型增生（3%）；2 例复杂性不典型增生（3%）；2 例局灶性黏膜内子宫内膜样腺癌（3%）。总的来说，子宫内膜呈异质性，大多数病变并未累及整个子宫内膜。总之，在检查了整个子宫内膜后，发现无症状女性的子宫内膜病变发生率非常高。这些病变的临床意义尚不清楚，但可能经常存在无症状的子宫内膜病变。
