Adamkov M, Plank L
Katedry patologickej anatómie a súdneho lekárstva LFUK v Martine.
Bratisl Lek Listy. 1990 Jun;91(6):433-6.
The paper analyzes the histopathologic pattern of 30 bioptically assessed cases of nodular-sclerotic (NS) type of Hodgkin's disease diagnosed before onset of therapy. The ratio of lymphocytes and tumor cells, as well signs of atypia, pleomorphism and blastic proliferation of tumor cells were evaluated in each case. On the basis of this analysis, the NS type was divided into the subtype NS 1 (14 cases) and subtype NS 2 (16 cases). In the subtype NS 1 lymphocytes were predominant in the tumor nodes and there were only few Sternberg-Reed cells, which were either isolated or in small clusters. Fibrosis in the tumor nodes was mild. In the subtype NS 2 the ratio of lymphocytes was lower, Sternberg-Reed cells were numerous and were found to be in groups and clusters. Pleomorphism and atypia of the tumor cells was remarkable. Pronounced fibrosis was seen in the nodes. The ratio of reactive cells and necroses exhibited individual variation in both subtypes. Statistical evaluation of survival time showed significant differences between the patients with subtype NS 1 and NS 2. Differentiation between NS 1 and NS 2 subtypes of the nodular-sclerotic type of Hodgkin's disease can thus ben considered to be prognostically relevant.
本文分析了30例在治疗开始前经活检评估的结节硬化型（NS）霍奇金病的组织病理学模式。评估了每例患者淋巴细胞与肿瘤细胞的比例，以及肿瘤细胞的异型性、多形性和母细胞增殖迹象。基于该分析，NS型被分为NS 1亚型（14例）和NS 2亚型（16例）。在NS 1亚型中，肿瘤结节内淋巴细胞占主导，仅有少数施特恩伯格-里德细胞，这些细胞要么孤立存在，要么呈小簇状。肿瘤结节内的纤维化程度较轻。在NS 2亚型中，淋巴细胞比例较低，施特恩伯格-里德细胞数量众多，呈成群或成簇状。肿瘤细胞的多形性和异型性显著。结节内可见明显纤维化。反应性细胞与坏死的比例在两种亚型中均表现出个体差异。生存时间的统计学评估显示，NS 1亚型和NS 2亚型患者之间存在显著差异。因此，可以认为结节硬化型霍奇金病的NS 1和NS 2亚型之间的区分具有预后相关性。
