Department of Neurosciences, Monash Medical Centre, Clayton, VIC, Australia.
J Parkinsons Dis. 2012;2(4):269-71. doi: 10.3233/JPD-012121.
Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the "on" and "off" states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD.
尽管有报道称，对于 G2019S 亮氨酸重复激酶 2（LRRK2）帕金森病患者，有效的深部脑刺激（STN-DBS）可作用于丘脑底核（STN），但对于其他 LRRK2 突变患者，手术治疗的效果尚未见报道。我们报告了一例来自林肯郡家系（Y1699C）的患者，对其进行双侧 STN-DBS 以控制严重的运动波动和运动障碍。在“开”和“关”状态下，他的统一帕金森病评定量表（UPDRS）第三部分评分均有显著改善，且持续了三年多。伴有 Y1699C 突变的 LRRK2 帕金森病患者接受双侧 STN-DBS 治疗的效果与散发性 PD 患者相似。
