Holdaway I M, Mason B H, Marshall R J, Neave L M, Kay R G
Department of Endocrinology, Auckland Hospital, New Zealand.
Cancer Res. 1990 Sep 15;50(18):5883-6.
There are conflicting reports of seasonal changes in steroid hormone receptor levels in breast cancer tissue. Estrogen receptor and progesterone (PR) receptor levels from 1132 tumors were thus grouped according to month of initial tumor detection or month of tissue sampling/surgery. There was a significant circannual variation in the mean monthly PR receptor concentration in patients grouped according to month of tissue sampling/surgery with peak PR levels in April (late summer-early autumn) and nadir values in August and September (late winter-early spring). There was no significant cyclic variation in estrogen receptor values. A significant annual variation in tumor PR concentration was also seen when receptor levels from individual tumors were grouped according to month of initial tumor detection, with peak PR levels found in January and February. The time interval between tumor detection and biopsy/surgery was 3.3 +/- 5.3 months (mean +/- SD) which was close to the interval between the peak PR concentration expressed by month of tumor detection compared with month of tissue sampling for receptor assay. There was also a significant seasonal variation in the month of initial tumor detection, with peak detection occurring in December (summer). The close synchrony between month of maximum tumor detection and month of peak PR concentration suggests that seasonal changes in detection of breast cancer may in part relate to seasonal changes in hormone responsiveness within tumor tissue.
关于乳腺癌组织中类固醇激素受体水平的季节性变化，存在相互矛盾的报道。因此，根据肿瘤初次检测月份或组织采样/手术月份，对1132例肿瘤的雌激素受体和孕激素（PR）受体水平进行了分组。根据组织采样/手术月份分组的患者中，平均每月PR受体浓度存在显著的年度周期性变化，PR水平在4月（夏末-初秋）达到峰值，在8月和9月（冬末-早春）达到最低值。雌激素受体值没有显著的周期性变化。当根据肿瘤初次检测月份对单个肿瘤的受体水平进行分组时，肿瘤PR浓度也存在显著的年度变化，PR水平在1月和2月达到峰值。肿瘤检测与活检/手术之间的时间间隔为3.3±5.3个月（平均值±标准差），这与根据肿瘤检测月份与受体检测组织采样月份表示的PR浓度峰值之间的间隔接近。肿瘤初次检测月份也存在显著的季节性变化，12月（夏季）检测到的肿瘤数量最多。肿瘤检测最多的月份与PR浓度峰值月份之间的紧密同步表明，乳腺癌检测的季节性变化可能部分与肿瘤组织内激素反应性的季节性变化有关。
