Akslen L A, Sothern R B
Department of Pathology, The Gade Institute, University of Bergen, Norway.
Br J Cancer. 1998 Apr;77(7):1174-9. doi: 10.1038/bjc.1998.195.
Seasonal variation has been described in the presentation and growth of several malignant tumours, including cancers of the breast, uterus, uterine cervix, urinary bladder, liver, lymphatic system and skin, although the mechanisms are not known. We herein describe a circannual rhythm for thyroid cancer (total = 2627), with significantly more cases presenting during the late autumn and winter. In a subset of these cases (127 papillary carcinomas), significant seasonal variations with highest values in autumn-winter were found for tumour diameter and proliferation indicators (S- and G2M-phase fractions). These results indicate the likelihood of a seasonal factor (or factors) of importance for the regulation and modification of tumour cell proliferation. When further clarified, this might be of relevance for the planning of diagnostic and therapeutic strategies.
已有研究描述了几种恶性肿瘤（包括乳腺癌、子宫癌、宫颈癌、膀胱癌、肝癌、淋巴系统癌和皮肤癌）在发病和生长方面的季节性变化，但其机制尚不清楚。我们在此描述了甲状腺癌的年周期节律（共计2627例），发现晚秋和冬季的病例明显更多。在这些病例的一个亚组（127例乳头状癌）中，发现肿瘤直径和增殖指标（S期和G2M期细胞比例）存在显著的季节性变化，秋冬季节的值最高。这些结果表明，存在一个对肿瘤细胞增殖的调节和改变具有重要意义的季节性因素。进一步明确后，这可能与诊断和治疗策略的规划相关。
