内源性逆转录病毒的概念与阐明。
On the concept and elucidation of endogenous retroviruses.
机构信息
Division of Infection and Immunity, Wohl Virion Centre, University College London, , Cruciform Building, Gower Street, London WC1 6BT, UK.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120494. doi: 10.1098/rstb.2012.0494. Print 2013 Sep 19.
Abstract
Endogenous retrovirus (ERV) genomes integrated into the chromosomal DNA of the host were first detected in chickens and mice as Mendelian determinants of Gag and Env proteins and of the release of infectious virus particles. The presence of ERV was confirmed by DNA hybridization. With complete host genomes available for analysis, we can now see the great extent of viral invasion into the genomes of numerous vertebrate species, including humans. ERVs are found at many loci in host DNA and also in the genomes of large DNA viruses, such as herpesviruses and poxviruses. The evolution of xenotropism and cross-species infection is discussed in the light of the dynamic relationship between exogenous and endogenous retroviruses.
摘要
内源性逆转录病毒 (ERV) 基因组整合到宿主的染色体 DNA 中，最初在鸡和小鼠中被检测为 Gag 和 Env 蛋白以及传染性病毒颗粒释放的孟德尔决定因素。ERV 的存在通过 DNA 杂交得到证实。随着完整的宿主基因组可供分析，我们现在可以看到病毒在包括人类在内的许多脊椎动物物种的基因组中广泛入侵。ERV 存在于宿主 DNA 的许多基因座中，也存在于疱疹病毒和痘病毒等大型 DNA 病毒的基因组中。根据外源性和内源性逆转录病毒之间的动态关系，讨论了嗜异性和跨物种感染的进化。
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1
Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation.“合胞素”的古病毒学：逆转录病毒外显子基因被特化用于胎盘形成。
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120507. doi: 10.1098/rstb.2012.0507. Print 2013 Sep 19.
2
Virology. Our viral inheritance.病毒学。我们的病毒遗传。
Science. 2013 May 17;340(6134):820-1. doi: 10.1126/science.1235148.
3
HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.人类胚胎干细胞中含有丰富的 HERV-H RNA，是多能性的精确标志物。
Retrovirology. 2012 Dec 20;9:111. doi: 10.1186/1742-4690-9-111.
4
Resurrection of endogenous retroviruses in antibody-deficient mice.抗体缺陷小鼠内源性逆转录病毒的复活。
Nature. 2012 Nov 29;491(7426):774-8. doi: 10.1038/nature11599. Epub 2012 Oct 24.
5
Unexpected diversity and expression of avian endogenous retroviruses.意想不到的禽类内源性逆转录病毒的多样性和表达。
mBio. 2012 Oct 16;3(5):e00344-12. doi: 10.1128/mBio.00344-12.
6
An endogenous foamy-like viral element in the coelacanth genome.腔棘鱼基因组中的内源性泡沫样病毒元件。
PLoS Pathog. 2012;8(6):e1002790. doi: 10.1371/journal.ppat.1002790. Epub 2012 Jun 28.
7
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Placenta. 2012 Sep;33(9):663-71. doi: 10.1016/j.placenta.2012.05.005. Epub 2012 Jun 12.
8
Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus.鉴定新型亚组 A 变异株，其在原发性贫血型猫白血病病毒分离株中具有增强的受体结合和复制能力。
Retrovirology. 2012 May 31;9:48. doi: 10.1186/1742-4690-9-48.
9
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Nat Rev Microbiol. 2012 May 8;10(6):395-406. doi: 10.1038/nrmicro2783.
10
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Proc Natl Acad Sci U S A. 2012 May 8;109(19):7385-90. doi: 10.1073/pnas.1200913109. Epub 2012 Apr 23.
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