Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Neurosci Lett. 2013 Sep 27;552:146-50. doi: 10.1016/j.neulet.2013.07.055. Epub 2013 Aug 9.
Adrenomedullin (AM), a member of the calcitonin gene-related peptide (CGRP) family, has been demonstrated to be a pronociceptive mediator. This study was undertaken to investigate the role of AM in acute inflammatory pain induced by formalin injection in rats. Interestingly Cerebrospinal fluid (CSF) levels of AM increased 45 min after formalin injection and a selective AM receptor antagonist, AM22-52, administered intrathecally (i.t.) decreased phase 2 flinching in a dose-dependent manner but not phase 1 flinching during the formalin test. This anti-hyperalgesic effect of i.t. AM22-52 lasted for 4 h or more. AM in the CSF contributes to the modulation of acute inflammatory pain in the formalin test, and blocking downstream signaling effects of the AM receptor has the potential to relieve pain associated with acute inflammation.
肾上腺髓质素 (AM) 是降钙素基因相关肽 (CGRP) 家族的成员，已被证明是一种致痛介质。本研究旨在探讨 AM 在福尔马林注射诱导的大鼠急性炎症性疼痛中的作用。有趣的是，福尔马林注射后 45 分钟，脑脊液 (CSF) 中 AM 水平升高，鞘内 (i.t.) 给予选择性 AM 受体拮抗剂 AM22-52 可剂量依赖性地减少第 2 相退缩，但不减少第 1 相退缩在福尔马林试验期间。鞘内注射 AM22-52 的这种抗痛觉过敏作用可持续 4 小时或更长时间。CSF 中的 AM 有助于调节福尔马林试验中的急性炎症性疼痛，阻断 AM 受体的下游信号作用有可能缓解与急性炎症相关的疼痛。
