Li Feng-Jiao, Zheng Si-Ru, Wang Dong-Mei
College of Life Sciences, Laboratory of Neuroendocrinology, Provincial Key Laboratory of Developmental Biology and Neuroscience, Fujian Normal University, Fuzhou, Fujian Province, China.
Neural Regen Res. 2020 Jul;15(7):1199-1207. doi: 10.4103/1673-5374.272567.
Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown to act as an upstream factor in the transmission of noxious information for various types of pathological pain including acute and chronic inflammatory pain, cancer pain, neuropathic pain induced by spinal nerve injury and diabetic neuropathy. Initiation of glia-neuron signaling networks in the peripheral and central nervous system by adrenomedullin is involved in the formation and maintenance of morphine tolerance. Adrenomedullin has been shown to exert a facilitated or neuroprotective effect against brain injury including hemorrhagic or ischemic stroke and traumatic brain injury. Additionally, adrenomedullin can serve as a regulator to promote nerve regeneration in pathological conditions. Therefore, adrenomedullin is an important participant in nervous system diseases.
肾上腺髓质素是一种在神经系统损伤和疾病中具有多种生理功能的肽，已引起研究人员的兴趣。本综述总结了肾上腺髓质素在神经病理疾病中的作用，包括病理性疼痛、脑损伤和神经再生及其治疗。作为一种新发现的伤害感受性介质，肾上腺髓质素已被证明在各种病理性疼痛（包括急性和慢性炎症性疼痛、癌痛、脊髓神经损伤诱导的神经性疼痛和糖尿病性神经病变）的有害信息传递中作为上游因子发挥作用。肾上腺髓质素在外周和中枢神经系统中启动胶质细胞 - 神经元信号网络，参与吗啡耐受性的形成和维持。肾上腺髓质素已被证明对包括出血性或缺血性中风以及创伤性脑损伤在内的脑损伤具有促进或神经保护作用。此外，肾上腺髓质素可作为一种调节剂，在病理条件下促进神经再生。因此，肾上腺髓质素是神经系统疾病的重要参与者。
