Inserm, U913, Nantes, France.
J Parkinsons Dis. 2011;1(4):389-94. doi: 10.3233/JPD-2011-11061.
Olfactory dysfunction (OD) and constipation are two frequent and early non-motor features of Parkinson's disease (PD). Colonic PD neuropathology, the putative cause of constipation, can be analyzed and quantified using routine colonic biopsies and parallels disease severity. The present study was aimed at investigating whether the severity of neuropathology in the colon in PD is related to OD. Twenty-six PD patients were included. Colonic neuropathology, i.e., the density of Lewy pathology and the number of submucosal neurons, was unrelated to OD as assessed using the University of Pennsylvania Smell Identification. This suggests that unlike colonic Lewy pathology, OD is unrelated to disease severity.
嗅觉功能障碍（OD）和便秘是帕金森病（PD）的两种常见且早期的非运动特征。结肠 PD 神经病理学是便秘的潜在原因，可以通过常规结肠活检进行分析和定量，并与疾病严重程度相平行。本研究旨在探讨 PD 患者结肠神经病理学的严重程度与 OD 是否相关。共纳入 26 例 PD 患者。使用宾夕法尼亚大学嗅觉识别测试评估 OD，结果发现结肠神经病理学，即 Lewy 病理密度和黏膜下神经元数量与 OD 无关。这表明，与结肠 Lewy 病理不同，OD 与疾病严重程度无关。
