Department of Anatomy, School of Health Sciences, Fujita Health University, Toyoake, Japan.
Microsc Res Tech. 2011 Sep;74(9):819-24. doi: 10.1002/jemt.20961. Epub 2010 Nov 17.
We investigated the distribution of T lymphocytes, B lymphocytes, and S-100 protein-immunoreactive dendritic-like in the anal tonsil of the laboratory shrew, Suncus murinus. In adult animals, T lymphocytes were located mainly at the periphery of the anal tonsil, especially around small blood vessels. B lymphocytes were located in the central and subepithelial region of the anal tonsil, which includes primary lymphoid follicles, and in which there are small numbers of scattered T lymphocytes. B and T lymphocytes were distributed over 72.7 and 27.3% of the tonsillar area, respectively. However, their areas of distribution were not clearly distinguished. The areas containing B lymphocytes were enriched in S-100 protein antibody-immunoreactive cells, which exhibited a dendritic shape. These S-100-positive cells appeared to be identical to the follicular dendritic cells (FDC) seen in the follicles of lymphoid organs. These results suggest that the anal tonsils constitute one of the gut-associated lymphoid tissues (GALT), and that a function of the anal tonsil includes the capture of intruding antigens that would generate protective antibody responses.
我们研究了 T 淋巴细胞、B 淋巴细胞和 S-100 蛋白免疫反应性树突状样细胞在实验室鼩鼱肛门扁桃体中的分布。在成年动物中，T 淋巴细胞主要位于肛门扁桃体的外周，特别是在小血管周围。B 淋巴细胞位于肛门扁桃体的中央和黏膜下层区域，其中包括初级淋巴滤泡，并且其中有少量散在的 T 淋巴细胞。B 和 T 淋巴细胞分别分布在扁桃体区域的 72.7%和 27.3%。然而，它们的分布区域没有明显区分。含有 B 淋巴细胞的区域富含 S-100 蛋白抗体免疫反应性细胞，呈树突状。这些 S-100 阳性细胞似乎与淋巴器官滤泡中的滤泡树突状细胞（FDC）相同。这些结果表明，肛门扁桃体构成了肠道相关淋巴组织（GALT）之一，肛门扁桃体的功能包括捕获侵入的抗原，从而产生保护性抗体反应。
