奇异游动放线菌 DSM 43827 中假糖生物合成替代途径的比较代谢组学分析。
Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827.
机构信息
Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA).
出版信息
Chembiochem. 2013 Sep 2;14(13):1548-51. doi: 10.1002/cbic.201300384. Epub 2013 Aug 12.
Abstract
Through a combination of genome mining, gene knockouts, and comparative metabolomic studies, a new biosynthetic pathway to validoxylamine A has been discovered in DSM 43827. The study revealed the rich diversity of biosynthetic pathways to pseudosugar-containing natural products.
摘要
通过基因组挖掘、基因敲除和比较代谢组学研究，在 DSM 43827 中发现了_validoxylamine A 的新生物合成途径。该研究揭示了含有假糖的天然产物生物合成途径的丰富多样性。
相似文献
1
Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827.奇异游动放线菌 DSM 43827 中假糖生物合成替代途径的比较代谢组学分析。
Chembiochem. 2013 Sep 2;14(13):1548-51. doi: 10.1002/cbic.201300384. Epub 2013 Aug 12.
2
Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source.以果糖作为唯一碳源时，奇异放线菌对安丝菌素P-3产量的提高。
Appl Biochem Biotechnol. 2015 Mar;175(6):2845-56. doi: 10.1007/s12010-014-1445-6. Epub 2015 Jan 7.
3
Actinosynnema mirum, a new producer of nocardicin antibiotics.
J Antibiot (Tokyo). 1983 Mar;36(3):321-4. doi: 10.7164/antibiotics.36.321.
4
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.追踪生物转化至基因水平：从嗜热放线菌中鉴定出一种高度灵活的糖基转移酶。
Appl Environ Microbiol. 2013 Sep;79(17):5224-32. doi: 10.1128/AEM.01652-13. Epub 2013 Jun 21.
5
Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE.假糖基转移酶VldE的独特底物特异性和催化活性
Chem Biol. 2015 Jun 18;22(6):724-33. doi: 10.1016/j.chembiol.2015.04.021. Epub 2015 Jun 4.
6
Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum.从奇异游动放线菌中分离、结构阐明和生物合成一种含有羟肟酸酯的非典型铁载体。
J Nat Prod. 2012 May 25;75(5):905-14. doi: 10.1021/np300046k. Epub 2012 May 11.
7
Mirilactams C-E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium.米里内酰胺C-E，从奇异放线菌NBRC 14064与含分枝菌酸细菌的混合培养物中分离得到的新型多环大环内酰胺。
Chem Pharm Bull (Tokyo). 2018;66(6):660-667. doi: 10.1248/cpb.c18-00143.
8
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.由美丽放线菌合成抗肿瘤药物安丝菌素过程中聚酮合酶后的修饰步骤。
J Am Chem Soc. 2003 Nov 26;125(47):14236-7. doi: 10.1021/ja038166y.
9
A direct, efficient method for the preparation of siRNAs containing ribo-like North bicyclo[3.1.0]hexane pseudosugars.一种直接、高效的方法，用于制备含有核糖样北双环[3.1.0]己烷假糖的 siRNAs。
Org Lett. 2011 Jun 3;13(11):2888-91. doi: 10.1021/ol200909j. Epub 2011 May 9.
10
Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.利用珍贵放线菌作为生物催化剂将合成的开链原安丝菌素环化生成安丝菌素大环内酰胺。
Chembiochem. 2010 Dec 10;11(18):2517-20. doi: 10.1002/cbic.201000422.
引用本文的文献
1
Synthesis of the Carba-Analogs of the α-Pyranose and β-Pyranose Forms of Sedoheptulose 7-Phosphate and Probing the Stereospecificity of Sedoheptulose 7-Phosphate Cyclases.合成 Sedoheptulose 7-磷酸的α-吡喃糖和β-吡喃糖形式的碳杂类似物，并探究 Sedoheptulose 7-磷酸环化酶的立体特异性。
Biochemistry. 2024 May 21;63(10):1359-1368. doi: 10.1021/acs.biochem.4c00034. Epub 2024 Apr 30.
2
Catalytic Mechanism of Nonglycosidic C-N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE.假糖基转移酶VldE催化非糖苷C-N键形成的机制
ACS Catal. 2023 Oct 20;13(20):13369-13382. doi: 10.1021/acscatal.3c02404. Epub 2023 Oct 3.
3
Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.通过引入工程化辅因子自给自足系统改进L-苯甘氨酸的合成。
Synth Syst Biotechnol. 2021 Dec 22;7(1):513-521. doi: 10.1016/j.synbio.2021.12.008. eCollection 2022 Mar.
4
The Differences of Graphene Oxide Products Made from Three Kinds of Flake Graphites.三种鳞片石墨制备的氧化石墨烯产物的差异
ACS Omega. 2021 Sep 28;6(40):25996-26003. doi: 10.1021/acsomega.1c02845. eCollection 2021 Oct 12.
5
-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.- 参与抗肿瘤 dnacin B1 醌部分形成的苯丙氨酸。
Molecules. 2020 Sep 12;25(18):4186. doi: 10.3390/molecules25184186.
6
Biosynthesis and Metabolic Engineering of Pseudo-oligosaccharides.假寡糖的生物合成与代谢工程
Emerg Top Life Sci. 2018;2(3):405-417. doi: 10.1042/ETLS20180010. Epub 2018 Aug 30.
7
The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology.景天庚酮糖7-磷酸环化酶及其在生物学和生态学中的新作用。
Nat Prod Rep. 2017 Aug 2;34(8):945-956. doi: 10.1039/c7np00017k.
8
Evolution and Distribution of C-Cyclitol Synthases in Prokaryotes and Eukaryotes.原核生物和真核生物中C-环糖醇合酶的进化与分布
ACS Chem Biol. 2017 Apr 21;12(4):979-988. doi: 10.1021/acschembio.7b00066. Epub 2017 Feb 17.
9
Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE.假糖基转移酶VldE的独特底物特异性和催化活性
Chem Biol. 2015 Jun 18;22(6):724-33. doi: 10.1016/j.chembiol.2015.04.021. Epub 2015 Jun 4.
本文引用的文献
1
Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.7-磷酸景天庚酮糖环化酶的进化分歧导致了几种不同的环状产物。
J Am Chem Soc. 2012 Jul 25;134(29):12219-29. doi: 10.1021/ja3041866. Epub 2012 Jul 5.
2
Annotation of plant gene function via combined genomics, metabolomics and informatics.通过整合基因组学、代谢组学和信息学对植物基因功能进行注释。
J Vis Exp. 2012 Jun 17(64):e3487. doi: 10.3791/3487.
3
Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function".代谢组学作为一种生成假说的功能基因组学工具，用于注释拟南芥中“未知功能”的基因。
Front Plant Sci. 2012 Feb 10;3:15. doi: 10.3389/fpls.2012.00015. eCollection 2012.
4
Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum.从奇异游动放线菌中分离、结构阐明和生物合成一种含有羟肟酸酯的非典型铁载体。
J Nat Prod. 2012 May 25;75(5):905-14. doi: 10.1021/np300046k. Epub 2012 May 11.
5
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.参与吲哚咔唑生物合成中吡咯氧化反应的StaC和RebC的表征及功能修饰。
Biosci Biotechnol Biochem. 2011;75(11):2184-93. doi: 10.1271/bbb.110474. Epub 2011 Nov 7.
6
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.假糖基转移酶催化 validamycin A 生物合成中的非糖基 C-N 偶联。
J Am Chem Soc. 2011 Aug 10;133(31):12124-35. doi: 10.1021/ja203574u. Epub 2011 Jul 18.
7
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.antiSMASH：快速识别、注释和分析细菌和真菌基因组序列中次生代谢产物生物合成基因簇。
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W339-46. doi: 10.1093/nar/gkr466. Epub 2011 Jun 14.
8
Advances in mass spectrometry applied to pharmaceutical metabolomics.质谱学在药物代谢组学中的应用进展。
Anal Bioanal Chem. 2011 Mar;399(8):2645-53. doi: 10.1007/s00216-010-4370-8. Epub 2010 Nov 25.
9
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.来自内共生细菌放线菌属菌株Lu 9419的一种不寻常氨基环醇——西托尼亚酮A的生物合成基因簇。
Chembiochem. 2009 Jan 26;10(2):304-14. doi: 10.1002/cbic.200800527.
10
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.ValC，一种参与抗真菌剂井冈霉素A生物合成的新型C7-环醇激酶。
Chembiochem. 2007 Apr 16;8(6):632-41. doi: 10.1002/cbic.200600528.
Zotero 插件