重度抑郁症患者QT离散度和P波离散度增加。
Increased QT dispersion and P wave dispersion in major depressive disorder.
作者信息
Tosu Aydin Rodi, Demir Serafettin, Kaya Yüksel, Selcuk Murat, Asker Müntecep, Ozdemir Mahmut, Tenekecioglu Erhan
机构信息
Department of Cardiology, Van Training and Research Hospital, Van, Turkey.
出版信息
Exp Clin Cardiol. 2013 Spring;18(2):110-2.
BACKGROUND
QT and P wave dispersion parameters can indicate abnormalities in autonomic nervous system and cardiac functioning.
OBJECTIVES
To determine QT and P wave dispersion in patients with major depressive disorder compared with healthy volunteers.
METHODS
Fifty newly diagnosed patients with major depressive disorder and 50 age- and sex-matched healthy volunteers underwent 12-lead electrocardiography. QT interval, QT dispersion, heart rate-corrected QT dispersion and P wave dispersions were calculated manually by a blinded specialist.
RESULTS
Groups were comparable in terms of age, sex, body mass index, smoking status, metabolic diseases and left ventricular ejection fraction. The major depressive disorder group had significantly higher QT dispersion (58.5±9.9 versus 41.7±3.8; P<0.001), heart rate-corrected QT dispersion (62.5±10.0 versus 45.2±4.3; P<0.001) and P wave dispersion (46.9±4.8 versus 41.5±5.1; P<0.001).
CONCLUSION
Increased QT dispersion, heart-rate corrected QT dispersion and P wave dispersion in major depressive disorder patients may be indicative of autonomic imbalance and increased risk of cardiac morbidity and mortality.
背景
QT间期和P波离散度参数可提示自主神经系统及心脏功能异常。
目的
比较重度抑郁症患者与健康志愿者的QT间期和P波离散度。
方法
对50例新诊断的重度抑郁症患者和50例年龄及性别匹配的健康志愿者进行12导联心电图检查。由一名不知情的专家手动计算QT间期、QT离散度、心率校正QT离散度和P波离散度。
结果
两组在年龄、性别、体重指数、吸烟状况、代谢性疾病和左心室射血分数方面具有可比性。重度抑郁症组的QT离散度（58.5±9.9对41.7±3.8；P<0.001）、心率校正QT离散度（62.5±10.0对45.2±4.3；P<0.001）和P波离散度（46.9±4.8对41.5±5.1；P<0.001）显著更高。
结论
重度抑郁症患者QT离散度、心率校正QT离散度和P波离散度增加可能提示自主神经失衡以及心脏发病和死亡风险增加。
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