NF/TSC Cure Org., Melbourne, Australia.
Phytother Res. 2014 May;28(5):656-72. doi: 10.1002/ptr.5054. Epub 2013 Aug 14.
Over 35 years research on PAKs, RAC/CDC42(p21)-activated kinases, comes of age, and in particular PAK1 has been well known to be responsible for a variety of diseases such as cancer (mainly solid tumors), Alzheimer's disease, acquired immune deficiency syndrome and other viral/bacterial infections, inflammatory diseases (asthma and arthritis), diabetes (type 2), neurofibromatosis, tuberous sclerosis, epilepsy, depression, schizophrenia, learning disability, autism, etc. Although several distinct synthetic PAK1-blockers have been recently developed, no FDA-approved PAK1 blockers are available on the market as yet. Thus, patients suffering from these PAK1-dependent diseases have to rely on solely a variety of herbal therapeutics such as propolis and curcumin that block PAK1 without affecting normal cell growth. Furthermore, several recent studies revealed that some of these herbal therapeutics significantly extend the lifespan of nematodes (C. elegans) and fruit flies (Drosophila), and PAK1-deficient worm lives longer than the wild type. Here, I outline mainly pathological phenotypes of hyper-activated PAK1 and a list of herbal therapeutics that block PAK1, but cause no side (harmful) effect on healthy people or animals.
超过 35 年的 PAKs（RAC/CDC42(p21)-activated kinases）研究已经成熟，特别是 PAK1 已被证实与多种疾病有关，如癌症（主要是实体瘤）、阿尔茨海默病、获得性免疫缺陷综合征和其他病毒/细菌感染、炎症性疾病（哮喘和关节炎）、糖尿病（2 型）、神经纤维瘤病、结节性硬化症、癫痫、抑郁症、精神分裂症、学习障碍、自闭症等。尽管最近已经开发出几种不同的合成 PAK1 抑制剂，但目前市场上还没有获得 FDA 批准的 PAK1 抑制剂。因此，患有这些 PAK1 依赖性疾病的患者只能依赖各种草药疗法，如蜂胶和姜黄素，这些疗法可以阻断 PAK1 而不影响正常细胞生长。此外，最近的几项研究表明，这些草药疗法中的一些可以显著延长线虫（秀丽隐杆线虫）和果蝇（黑腹果蝇）的寿命，并且缺乏 PAK1 的线虫比野生型线虫寿命更长。在这里，我主要概述了过度激活的 PAK1 的病理表型以及一些可以阻断 PAK1 但对健康人群或动物没有副作用（有害）的草药疗法。
