Sonar Sanchaita S, Dudda Jan C
Institute for Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
Methods Mol Biol. 2013;1032:229-34. doi: 10.1007/978-1-62703-496-8_18.
The bronchial epithelium has been increasingly recognized as an important immunomodulatory compartment in asthma and other lung diseases. Clara cells, which comprise the nonciliated secretory epithelial cells, are an important epithelial cell type with functions in the regulation of lung homeostasis and inflammation. Using naphthalene, Clara cells can be depleted within 24 h and regenerate by 1 month, hence, providing an easy method to study the impact of Clara cells on lung inflammation.
支气管上皮在哮喘和其他肺部疾病中作为一个重要的免疫调节区室已越来越受到认可。克拉拉细胞构成了无纤毛的分泌上皮细胞，是一种重要的上皮细胞类型，在调节肺内稳态和炎症方面发挥作用。使用萘，克拉拉细胞可在24小时内被清除，并在1个月内再生，因此，提供了一种研究克拉拉细胞对肺部炎症影响的简便方法。
