Department of Physical Therapy (LIM 34), University of São Paulo, School of Medicine, Avenida Doutor Arnaldo 455, São Paulo, Brazil.
Respir Physiol Neurobiol. 2011 Mar 15;175(3):383-9. doi: 10.1016/j.resp.2011.01.002. Epub 2011 Jan 12.
Airway epithelium plays an important role in the asthma physiopathology. Aerobic exercise decreases Th2 response in murine models of allergic asthma, but its effects on the structure and activation of airway epithelium in asthma are unknown. BALB/c mice were divided into control, aerobic exercise, ovalbumin-sensitized and ovalbumin-sensitized plus aerobic exercise groups. Ovalbumin sensitization occurred on days 0, 14, 28, 42, and aerosol challenge from day 21 to day 50. Aerobic exercise started on day 22 and ended on day 50. Total cells and eosinophils were reduced in ovalbumin-sensitized group submitted to aerobic exercise. Aerobic exercise also reduced the oxidative and nitrosative stress and the epithelial expression of Th2 cytokines, chemokines, adhesion molecules, growth factors and NF-kB and P2X7 receptor. Additionally, aerobic exercise increased the epithelial expression of IL-10 in non-sensitized and sensitized animals. These findings contribute to the understanding of the beneficial effects of aerobic exercise for chronic allergic airway inflammation, suggesting an immune-regulatory role of exercise on airway epithelium.
气道上皮在哮喘病理生理学中起着重要作用。有氧运动可降低变应性哮喘小鼠模型中的 Th2 反应，但它对哮喘气道上皮的结构和激活的影响尚不清楚。BALB/c 小鼠分为对照组、有氧运动组、卵清蛋白致敏组和卵清蛋白致敏加有氧运动组。卵清蛋白致敏于第 0、14、28、42 天进行，第 21 天至第 50 天进行雾化挑战。有氧运动于第 22 天开始，第 50 天结束。有氧运动可减少卵清蛋白致敏组的总细胞和嗜酸性粒细胞。有氧运动还降低了氧化应激和硝化应激以及上皮细胞表达的 Th2 细胞因子、趋化因子、黏附分子、生长因子和 NF-kB 和 P2X7 受体。此外，有氧运动增加了非致敏和致敏动物的上皮细胞表达的 IL-10。这些发现有助于理解有氧运动对慢性变应性气道炎症的有益作用，提示运动对气道上皮具有免疫调节作用。
