[磷酸吡哆醛修饰的聚血红蛋白对哺乳动物红细胞聚集的影响]
[Effect of pyridoxal-5-phosphate-modified polyhemoglobin on mammals' erythrocyte aggregation].
作者信息
Smirnov I V, Groznaia T G, Khachatur'ian A A
出版信息
Gematol Transfuziol. 1990 May;35(5):14-6.
PMID:2394355
Abstract
Human red blood cells in vitro are most subjected to aggregating action of pyridoxal-5'-phosphate-modified polyhemoglobin (PPPH) as compared to red blood cells of other mammals--mouse, dog, rabbit, rat. A conclusion has been made that the study of rheologic properties of PPPH in the animals cannot completely reflect the aggregating action of this oxygen-carrier in case of its infusion to humans.
摘要
与其他哺乳动物（小鼠、狗、兔子、大鼠）的红细胞相比，体外培养的人类红细胞最容易受到磷酸吡哆醛修饰的多聚血红蛋白（PPPH）的聚集作用影响。由此得出结论：在动物身上研究PPPH的流变学特性，无法完全反映这种氧载体注入人体时的聚集作用。
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