Litvinenko Iu A, Kolonina I R, Sokolov A V, Gorbunova N A
Gematol Transfuziol. 1991 Aug;36(8):16-8.
The effectiveness of modified polyhemoglobin proposed as an artificial oxygen carrier (AOC) was evaluated in experiments on dogs with acute fatal hemorrhage. It was shown that total oxygen consumption, arterial blood pressure and circulating blood volume were maintained at the normal physiological levels during 4 h after infusion of 10% solution of polyhemoglobin. AOC infusion provided 100% survival of the animals. It has been concluded that hemoglobin polymer modified with pyridoxal-5'-phosphate can be used as the basis for the production of the medicinal form of AOC.
在急性致命性出血犬实验中评估了作为人工氧载体（AOC）的改性多聚血红蛋白的有效性。结果表明，输注10%多聚血红蛋白溶液后4小时内，总耗氧量、动脉血压和循环血容量维持在正常生理水平。AOC输注使动物存活率达到100%。得出结论：用磷酸吡哆醛改性的血红蛋白聚合物可作为生产AOC药用形式的基础。
