Iavorkovskiĭ L L, Merson A G, Gipsh N M, Karminskaia N M, Nikul'shin S V, Guseva L N, Iavorkovskiĭ L I
Gematol Transfuziol. 1990 Jun;35(6):12-6.
A total of 5 patients with a clinicohematological picture resembling hairy-cell leukemia (HCL) have been described. However, the morphological features of leukemic lymphocytes, the absence of acid phosphatase in them, the nodular character of the bone marrow lesion combined with an unusual phenotype have permitted the authors to distinguish these cases as a separate variant of B-cell malignant lymphoma. Paraprotein (M-class) was detected in the blood of two of the patients. A conclusion has been made that the combination of splenomegaly with hairy lymphocytes in the blood is characteristic of not only HCL, but it can be also observed in different variants of malignant lymphoma.
共描述了5例临床血液学表现类似毛细胞白血病(HCL)的患者。然而,白血病淋巴细胞的形态特征、其中酸性磷酸酶的缺乏、骨髓病变的结节性特征以及异常的表型使作者能够将这些病例区分为B细胞恶性淋巴瘤的一种单独变体。两名患者的血液中检测到副蛋白(M类)。得出的结论是,脾肿大与血液中毛细胞同时出现不仅是HCL的特征,在恶性淋巴瘤的不同变体中也可观察到。