a Department of Psychiatry , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
J Clin Exp Neuropsychol. 2013;35(7):718-27. doi: 10.1080/13803395.2013.823910. Epub 2013 Aug 14.
Fatigue and cognitive impairment are common in HIV+ adults and may occur independently or be causally linked. This study examined whether alleviation of fatigue with armodafinil in a placebo-controlled double-blind 4-week trial had an effect on cognitive function among those with and without mild neuropsychological impairment at baseline. Sixty-one patients completed a standard battery of neuropsychological tests at study entry and Week 4: A total of 33 were randomized to armodafinil and 28 to placebo. While there was a significant effect of active medication on fatigue, cognitive performance measured by a global change score did not differ between treatment groups, or in those on active treatment with or without mild neuropsychological impairment.
疲劳和认知障碍在 HIV 阳性成年人中很常见，可能独立发生或存在因果关系。本研究旨在探讨在为期 4 周的安慰剂对照双盲试验中，使用阿莫达非尼缓解疲劳是否会对基线时有轻度神经心理障碍和无轻度神经心理障碍的患者的认知功能产生影响。61 名患者在研究入组时和第 4 周完成了标准神经心理测试：共有 33 名患者被随机分配到阿莫达非尼组，28 名患者被分配到安慰剂组。尽管药物治疗对疲劳有显著影响，但以总体变化评分衡量的认知表现，在治疗组之间、在接受药物治疗的患者（无论是否有轻度神经心理障碍）之间均无差异。
