莫达非尼对治疗疲劳的 HIV+患者认知功能的影响：一项安慰剂对照研究。
Modafinil effects on cognitive function in HIV+ patients treated for fatigue: a placebo controlled study.
机构信息
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
J Clin Exp Neuropsychol. 2010 Jun;32(5):474-80. doi: 10.1080/13803390903201769. Epub 2009 Nov 24.
Abstract
Both mild cognitive impairment and fatigue are common among people with HIV/AIDS. This study examined the efficacy of modafinil for HIV+ patients who sought treatment for fatigue in a placebo-controlled double-blind 4-week trial. A battery of standard neuropsychological tests was administered at study entry and Week 4, and change in performance was compared for 59 patients receiving modafinil versus 44 patients receiving placebo. A significant effect on fatigue was observed. In addition, cognitive performance, as measured by a global change score, improved more in the modafinil than in the placebo group although the effect was not specific to any cognitive domain.
摘要
在 HIV/AIDS 患者中，轻度认知障碍和疲劳都很常见。本研究在一项为期 4 周的安慰剂对照双盲试验中，评估了莫达非尼对因疲劳而寻求治疗的 HIV+患者的疗效。在研究开始时和第 4 周，对一系列标准神经心理学测试进行了评估，并比较了 59 名接受莫达非尼治疗的患者和 44 名接受安慰剂治疗的患者的表现变化。结果观察到疲劳有显著改善。此外，尽管认知表现的改善并非特定于任何认知领域，但莫达非尼组的全球变化评分优于安慰剂组。
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