School of Chemical Engineering, Yeungnam University , Gyeongsan 712-749, Republic of Korea.
Org Lett. 2013 Sep 6;15(17):4288-91. doi: 10.1021/ol4019908. Epub 2013 Aug 15.
A sequential Wolff rearrangement of 1-diazonaphthalen-2(1H)-ones followed by trapping of the ketene intermediate with primary and aromatic amines or alcohols and phenols in the presence of various aldehydes generates 1H-indene-3-carboxamides or 1H-indene-3-carboxylates. This constitutes an unprecedented three-component coupling reaction that allows for the synthesis of functionalized indene derivatives under catalyst-free thermal conditions.
1-重氮萘-2(1H)-酮进行连续 Wolff 重排，然后在各种醛存在下，用伯胺或醇以及酚捕获烯酮中间体，生成 1H-茚满-3-甲酰胺或 1H-茚满-3-羧酸酯。这构成了一种前所未有的三组分偶联反应，允许在无催化剂的热条件下合成官能化茚衍生物。
