功能性内镜鼻窦手术及额外使用丙酸氟替卡松滴鼻剂对合并哮喘的鼻息肉患者心理健康的影响
Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma.
作者信息
Nordin Steven, Olsson Petter, Hedén Blomqvist Ebba, Stjärne Pär, Ehnhage Anders
机构信息
Department of Psychology, Umeå University, Sweden.
出版信息
Acta Otolaryngol. 2013 Sep;133(9):939-43. doi: 10.3109/00016489.2013.783715.
CONCLUSION
A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment.
OBJECTIVE
To better understand effects of FPND and FESS on generic QoL.
METHODS
Sixty nasal polyposis patients with concomitant asthma completed participation in a randomized, double-blind, placebo-controlled, 14-week study in which they responded to the General Well-Being Schedule (GWBS).
RESULTS
GWBS scores (i) increased significantly after administration of FPND, independent of FESS (from lower than normal to normal), (ii) increased after FESS independent of FPND (from lower than normal to normal), and (iii) increased additively after FPND and FESS.
结论
丙酸氟替卡松滴鼻剂（FPND）与功能性鼻内镜鼻窦手术（FESS）联合治疗可改善生活质量（QoL）。与先前数据相比，结果表明，生活质量心理方面的通用测量指标可能比呼吸症状和临床参数测量指标更能准确反映患者对疾病及其治疗的感受。
目的
更好地了解FPND和FESS对通用生活质量的影响。
方法
60例伴有哮喘的鼻息肉患者完成了一项随机、双盲、安慰剂对照的14周研究，期间他们对总体幸福感量表（GWBS）进行了回应。
结果
GWBS评分（i）在使用FPND后显著增加，与FESS无关（从低于正常水平升至正常水平），（ii）在FESS后增加，与FPND无关（从低于正常水平升至正常水平），（iii）在FPND和FESS联合治疗后呈累加性增加。
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