Mendelsohn D, Mendelsohn L
S Afr Med J. 1975 Jun 14;49(25):1011-4.
The hydrogen ion, pepsin and bile acid binding properties of hydrotalcite (Altacite) were investigated in human gastric juice both in vitro and in vivo. Hydrotalcite is an efficient antacid in vivo and between pH 2,5 and 3,5 it binds and inactivates pepsin in vitro. The results in one case suggest that this also occurs in vivo. Hydrotalcite is capable of removing substantial amounts of bile acids from bile-containing gastric juice in vivo. The findings indicate that hydrotalcite could be a useful agent in the treatment of both gastric and duodenal ulcers.
在体外和体内的人体胃液中研究了水滑石（Altacite）的氢离子、胃蛋白酶和胆汁酸结合特性。水滑石在体内是一种有效的抗酸剂，在pH 2.5至3.5之间，它在体外结合并使胃蛋白酶失活。一个病例的结果表明，这在体内也会发生。水滑石能够在体内从含胆汁的胃液中去除大量胆汁酸。研究结果表明，水滑石可能是治疗胃溃疡和十二指肠溃疡的有用药物。
