Division of Cardiology, Yale Medical School, , New Haven, Connecticut, USA.
Heart. 2013 Oct;99(20):1488-93. doi: 10.1136/heartjnl-2013-304649. Epub 2013 Aug 14.
Unstable coronary artery plaque is the most common underlying cause of acute coronary syndromes (ACS) and can manifest as unstable angina, non-ST segment elevation infarction (NSTE-ACS), and ST elevation myocardial infarction (STEMI), but can also manifest as sudden cardiac arrest due to ischaemia induced tachyarrhythmias. ACS mortality has decreased significantly over the last few years, especially from the more extreme manifestations of ACS, STEMI, and cardiac arrest. This trend is likely to continue based on recent therapeutic progress which includes novel antiplatelet agents such as prasugrel, ticagrelor, and cangrelor.
不稳定型冠状动脉斑块是急性冠状动脉综合征（ACS）最常见的潜在原因，可表现为不稳定型心绞痛、非 ST 段抬高型心肌梗死（NSTE-ACS）和 ST 段抬高型心肌梗死（STEMI），但也可因缺血诱导的快速性心律失常而导致心搏骤停。近年来，ACS 的死亡率显著下降，尤其是 ACS、STEMI 和心搏骤停等更为极端的表现形式。这种趋势可能会继续下去，这得益于最近的治疗进展，包括新型抗血小板药物，如普拉格雷、替格瑞洛和坎格瑞洛。
