Meier Pascal, Lansky Alexandra J, Baumbach Andreas
Division of Cardiology, Yale Medical School, New Haven, Connecticut-USA.
Anadolu Kardiyol Derg. 2014 Feb 11. doi: 10.5152/akd.2014.5552014.
Unstable coronary artery plaque is the most common underlying cause of acute coronary syndromes (ACS) and can manifest as unstable angina, non-ST segment elevation infarction (NSTE-ACS), and ST elevation myocardial infarction (STEMI), but can also manifest as sudden cardiac arrest due to ischaemia induced tachyarrhythmias. ACS mortality has decreased significantly over the last few years, especially from the more extreme manifestations of ACS, STEMI, and cardiac arrest. This trend is likely to continue based on recent therapeutic progress which includes novel antiplatelet agents such as prasugrel, ticagrelor, and cangrelor.
不稳定冠状动脉斑块是急性冠状动脉综合征（ACS）最常见的潜在病因，可表现为不稳定型心绞痛、非ST段抬高型心肌梗死（NSTE-ACS）和ST段抬高型心肌梗死（STEMI），但也可表现为因缺血诱发快速性心律失常导致的心搏骤停。在过去几年中，ACS死亡率显著下降，尤其是ACS、STEMI和心搏骤停等更严重表现形式导致的死亡率。基于近期的治疗进展，包括新型抗血小板药物如普拉格雷、替格瑞洛和坎格雷洛，这种趋势可能会持续下去。
