Azhar Zain M, Zubaidah Jamil O, Norjan Khin O N, Zhuang Candy Yi-Jing, Tsang Fai
Department of Psychiatry, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400UPM, Malaysia.
Nutr J. 2013 Aug 15;12:121. doi: 10.1186/1475-2891-12-121.
It has long been postulated that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that could be responsible for the action of diet on brain health and cognitive function. Here, through a double-blind, randomized, placebo-controlled trial, we asked if the newly discovered chicken meat ingredient-168 (CMI-168) could be beneficial to the cognitive function in healthy adults.
Normal, healthy subjects were supplemented with either placebo or CMI-168 for 6 weeks. The subjects were given a series of cognitive tests to examine their levels of cognitive functioning at the beginning and end of supplementation, as well as two weeks after termination of supplementation. The combination of these tests, namely Digit Span Backwards, Letter-Number Sequencing, and the Rey Auditory Verbal Learning Test (RAVLT), was used to assess the subjects' attention and working memory. For all comparisons, the probability level of p < 0.05 was taken as statistically significant using repeated measure 2-way ANOVA followed by Bonferroni post-hoc test.
Overall, subjects supplemented with CMI-168 showed significantly (p < 0.01) better performance in all cognitive tests after 6 weeks' supplementation compared to control and such superior performance was maintained even 2 weeks after termination of supplementation.
The present study reveals the cognition-enhancing properties of a recently developed chicken meat ingredient, likely arising from the promotion of attention and prefrontal cortex functions.
长期以来，人们一直推测特定营养素的相对丰度会影响认知过程和情绪。最近描述的饮食因素对神经元功能和突触可塑性的影响揭示了一些可能导致饮食对大脑健康和认知功能产生作用的重要机制。在此，我们通过一项双盲、随机、安慰剂对照试验，探究新发现的鸡肉成分168（CMI - 168）对健康成年人的认知功能是否有益。
正常健康受试者补充安慰剂或CMI - 168，为期6周。在补充开始和结束时，以及补充终止后两周，对受试者进行一系列认知测试，以检查他们的认知功能水平。这些测试组合，即倒背数字广度、字母 - 数字排序和雷伊听觉词语学习测试（RAVLT），用于评估受试者的注意力和工作记忆。对于所有比较，采用重复测量双向方差分析，然后进行Bonferroni事后检验，将p < 0.05的概率水平视为具有统计学意义。
总体而言，补充CMI - 168的受试者在补充6周后，在所有认知测试中的表现均显著（p < 0.01）优于对照组，并且即使在补充终止后2周，这种优异表现仍得以维持。
本研究揭示了一种最近开发的鸡肉成分具有增强认知的特性，这可能源于对注意力和前额叶皮层功能的促进。
