• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

水解鸡肉提取物（ProBeptigen）对健康中年人群认知功能的影响：一项随机双盲试验。

Hydrolyzed Chicken Extract (ProBeptigen) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial.

机构信息

Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, Taiwan.

School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

出版信息

Nutrients. 2020 May 10;12(5):1362. doi: 10.3390/nu12051362.

DOI:10.3390/nu12051362
PMID:32397609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7284526/
Abstract

Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of ProBeptigen® (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the ProBeptigen® or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The ProBeptigen® group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of ProBeptigen® in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of ProBeptigen® is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of ProBeptigen® on cognition warrant further investigation. (NCT03612752).

摘要

认知衰退是全球公共卫生的一个重要问题。认知衰老可能始于中年，这是一生中特别容易受到压力影响的时期。鸡的精华（EOC）一直被证明作为营养补充对各种认知领域都有有益的影响。本研究主要旨在探讨从 EOC 中提取的水解肽制成的 ProBeptigen®（以前称为 CMI-168）对轻度压力下健康中年人的认知增强作用。90 名健康受试者被随机分配到 ProBeptigen®或安慰剂组，进行为期 8 周的治疗。在治疗前、治疗中和治疗后进行神经认知评估、事件相关电位（ERP）和血液检查。在剑桥神经心理学测试自动化电池（CANTAB）中，韦氏记忆量表第三版（WMS-III）的逻辑记忆子测验和空间工作记忆任务中，ProBeptigen®组的表现优于安慰剂组。还证实了 ProBeptigen®在人类中的抗炎作用，高敏 C 反应蛋白（hs-CRP）水平逐渐下降。建议定期食用 ProBeptigen®补充剂，以改善中年健康人群的言语短期和长期记忆以及空间工作记忆，并减轻压力引起的炎症。ProBeptigen®对认知的影响值得进一步研究。（NCT03612752）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/fc9d3ae03e9d/nutrients-12-01362-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/2ef857f283a1/nutrients-12-01362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/f8117ef02e45/nutrients-12-01362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/4e64e1faed61/nutrients-12-01362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/90ff5e76cfb8/nutrients-12-01362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/22f229411f0a/nutrients-12-01362-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/ba3807b5d19a/nutrients-12-01362-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/fc9d3ae03e9d/nutrients-12-01362-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/2ef857f283a1/nutrients-12-01362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/f8117ef02e45/nutrients-12-01362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/4e64e1faed61/nutrients-12-01362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/90ff5e76cfb8/nutrients-12-01362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/22f229411f0a/nutrients-12-01362-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/ba3807b5d19a/nutrients-12-01362-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e67/7284526/fc9d3ae03e9d/nutrients-12-01362-g007.jpg

相似文献

1
Hydrolyzed Chicken Extract (ProBeptigen) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial.水解鸡肉提取物（ProBeptigen）对健康中年人群认知功能的影响：一项随机双盲试验。
Nutrients. 2020 May 10;12(5):1362. doi: 10.3390/nu12051362.
2
Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice.水解鸡提取物（Probeptigen®/Cmi-168）对快速老化小鼠记忆保持和大脑氧化应激的保护作用。
Nutrients. 2019 Aug 12;11(8):1870. doi: 10.3390/nu11081870.
3
Neuroprotective effects of ProBeptigen/CMI-168 on aging-induced cognitive decline and neuroinflammation in mice: a comparison with essence of chicken.ProBeptigen/CMI-168 对衰老诱导的小鼠认知衰退和神经炎症的神经保护作用：与鸡 精的比较。
Acta Biochim Biophys Sin (Shanghai). 2021 Mar 26;53(4):419-429. doi: 10.1093/abbs/gmab009.
4
A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects.一项针对健康受试者开展的关于一种专利鸡肉成分认知增强益处的安慰剂对照、双盲随机试验研究。
Nutr J. 2013 Aug 15;12:121. doi: 10.1186/1475-2891-12-121.
5
Effectiveness of Essence of Chicken on Cognitive Function Improvement: A Randomized Controlled Clinical Trial.参鸡汤对认知功能改善的有效性：一项随机对照临床试验。
Nutrients. 2018 Jun 29;10(7):845. doi: 10.3390/nu10070845.
6
Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance.黄斑叶黄素补充对脑源性神经营养因子、促炎细胞因子和认知表现的影响。
Physiol Behav. 2019 Nov 1;211:112650. doi: 10.1016/j.physbeh.2019.112650. Epub 2019 Aug 16.
7
The Effect of Long-Term Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals.长期补充提取物对认知表现、情绪和血管功能的影响：一项针对健康中年人的随机对照试验。
Nutrients. 2020 Aug 17;12(8):2475. doi: 10.3390/nu12082475.
8
Effectiveness of Essence of Chicken in Improving Cognitive Function in Young People Under Work-Related Stress: A Randomized Double-Blind Trial.鸡精对改善工作压力下年轻人认知功能的有效性：一项随机双盲试验
Medicine (Baltimore). 2016 May;95(19):e3640. doi: 10.1097/MD.0000000000003640.
9
Acute and Chronic Effects of Green Oat ( Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled Study in Healthy Humans.在健康成年人中，绿色燕麦（提取物）对认知功能和情绪的急性和慢性影响：一项在健康人体中进行的随机、双盲、安慰剂对照研究。
Nutrients. 2020 May 29;12(6):1598. doi: 10.3390/nu12061598.
10
Effect of Supplementation of a Whey Peptide Rich in Tryptophan-Tyrosine-Related Peptides on Cognitive Performance in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study.富含色氨酸-酪氨酸相关肽的乳清肽补充剂对健康成年人认知表现的影响：一项随机、双盲、安慰剂对照研究。
Nutrients. 2018 Jul 13;10(7):899. doi: 10.3390/nu10070899.

引用本文的文献

1
Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations.免疫调节食物蛋白衍生肽在人类营养干预中的证据：对结果和潜在局限性的综述。
Nutrients. 2023 Jun 8;15(12):2681. doi: 10.3390/nu15122681.
2
Dipeptide Extract Modulates the Oxi-Antioxidant Response to Intense Physical Exercise.二肽提取物调节剧烈运动的氧化抗氧化反应。
Nutrients. 2022 Jun 9;14(12):2402. doi: 10.3390/nu14122402.

本文引用的文献

1
Adherence to a Mediterranean diet is associated with cognitive function in an older non-Mediterranean sample: findings from the Maine-Syracuse Longitudinal Study.坚持地中海饮食与非地中海老年人群认知功能相关：来自缅因州-锡拉丘兹纵向研究的结果。
Nutr Neurosci. 2021 Jul;24(7):542-553. doi: 10.1080/1028415X.2019.1655201. Epub 2019 Aug 21.
2
Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice.水解鸡提取物（Probeptigen®/Cmi-168）对快速老化小鼠记忆保持和大脑氧化应激的保护作用。
Nutrients. 2019 Aug 12;11(8):1870. doi: 10.3390/nu11081870.
3
Daily consumption of essence of chicken improves cognitive function: a systematically searched meta-analysis of randomized controlled trials.
每日摄入鸡精可改善认知功能：一项系统检索的随机对照试验荟萃分析。
Nutr Neurosci. 2021 Mar;24(3):236-247. doi: 10.1080/1028415X.2019.1619984. Epub 2019 May 25.
4
Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study.中年系统性炎症与 20 年认知变化：ARIC 研究。
Neurology. 2019 Mar 12;92(11):e1256-e1267. doi: 10.1212/WNL.0000000000007094. Epub 2019 Feb 13.
5
A Hydrolyzed Chicken Extract CMI-168 Enhances Learning and Memory in Middle-Aged Mice.水解鸡提取物 CMI-168 可增强中年小鼠的学习和记忆能力。
Nutrients. 2018 Dec 22;11(1):27. doi: 10.3390/nu11010027.
6
Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.循环皮质醇与认知和结构脑测量：弗雷明汉心脏研究。
Neurology. 2018 Nov 20;91(21):e1961-e1970. doi: 10.1212/WNL.0000000000006549. Epub 2018 Oct 24.
7
Test-retest reliability and minimal detectable change of the Beck Depression Inventory and the Taiwan Geriatric Depression Scale in patients with Parkinson's disease.帕金森病患者中贝克抑郁量表和台湾老年抑郁量表的重测信度及最小可检测变化
PLoS One. 2017 Sep 25;12(9):e0184823. doi: 10.1371/journal.pone.0184823. eCollection 2017.
8
Impact of oral supplementation of Glutamate and GABA on memory performance and neurochemical profile in hippocampus of rats.口服补充谷氨酸和γ-氨基丁酸对大鼠海马体记忆表现和神经化学特征的影响。
Pak J Pharm Sci. 2017 May;30(3(Suppl.)):1013-1021.
9
Evidence for Cognitive Aging in Midlife Women: Study of Women's Health Across the Nation.中年女性认知衰老的证据：全国女性健康研究
PLoS One. 2017 Jan 3;12(1):e0169008. doi: 10.1371/journal.pone.0169008. eCollection 2017.
10
Effectiveness of Essence of Chicken in Improving Cognitive Function in Young People Under Work-Related Stress: A Randomized Double-Blind Trial.鸡精对改善工作压力下年轻人认知功能的有效性：一项随机双盲试验
Medicine (Baltimore). 2016 May;95(19):e3640. doi: 10.1097/MD.0000000000003640.