Kawasaki Yoshihide, Katayama Hiromichi, Kato Shinnosuke
The Department of Urology, Ogachi Central Hospital, Japan.
Hinyokika Kiyo. 2013 Jul;59(7):453-6.
Primary amyloidosis localized in the urinary bladder is comparatively rare,and 40% of the patients complain of lower urinary tract symptoms (LUTS). Although standard management for amyloidosis localized in the urinary bladder is not established,transurethral resection (TUR) is performed in most of the cases to diagnose the disease and to control bleeding. TUR is not considered as radical therapy for amyloidosis localized in the urinary bladder because of frequent recurrence. Dimethyl sulfoxide (DMSO) administered through intravenous,percutaneous or intravesical route has been shown to be effective for treating and preventing recurrence of the disease,but its effect on LUTS due to amyloidosis localized in the urinary bladder has not been demonstrated. We report a case showing improvement of LUTS and in which recurrence of amyloidosis localized in the urinary bladder was prevented for 18 months by intravesical DMSO therapy.
原发性膀胱淀粉样变性相对罕见，40%的患者有下尿路症状（LUTS）。尽管膀胱局限性淀粉样变性的标准治疗方法尚未确立，但大多数病例会进行经尿道切除术（TUR）以诊断疾病并控制出血。由于复发频繁，TUR不被视为膀胱局限性淀粉样变性的根治性治疗方法。通过静脉内、经皮或膀胱内途径给予二甲基亚砜（DMSO）已被证明对治疗和预防该疾病的复发有效，但其对膀胱局限性淀粉样变性所致LUTS的影响尚未得到证实。我们报告一例经膀胱内DMSO治疗后LUTS改善且膀胱局限性淀粉样变性复发被预防达18个月的病例。
