Rosén L, Ostergren J, Fagrell B, Stranden E
Vascular Research Laboratory, Aker Hospital, Oslo, Norway.
Int J Microcirc Clin Exp. 1990 Aug;9(3):257-66.
Disturbances of vasomotor activity and veno-arteriolar reflex mechanism probably promote cutaneous edema formation. Videophotometric capillaroscopy was used to measure nailfold skin capillary blood cell velocity (CBV) and its response to increased transmural pressure induced by venous occlusion in healthy subjects, normal pregnancies and patients with preeclampsia. Vasomotion, assessed by rhythmic variation of CBV, was also recorded. Both frequency (3-10 cycles/minute) and amplitude (0.01-0.23 mm/s) of CBV fluctuations were similar in all groups investigated. In healthy controls basal CBV was positively correlated with the amplitude of individual velocity fluctuations (r = 0.89). CBV response to venous occlusion was significantly reduced (p less than 0.05) in preeclampsia compared to normal pregnancies and non-pregnant controls. This finding indicates impaired veno-arteriolar reflex which may contribute to the edema formation seen in preeclampsia. It is suggested that vasomotor activity may serve as a physiological modulator of vascular resistance and hence CBV.
血管舒缩活动和静脉 - 小动脉反射机制紊乱可能促使皮肤水肿形成。在健康受试者、正常孕妇和先兆子痫患者中，采用视频光度毛细管镜检查来测量甲襞皮肤毛细血管血细胞速度（CBV）及其对静脉闭塞诱导的跨壁压力增加的反应。还记录了通过CBV的节律变化评估的血管运动。在所有研究组中，CBV波动的频率（3 - 10次/分钟）和幅度（0.01 - 0.23毫米/秒）相似。在健康对照组中，基础CBV与个体速度波动幅度呈正相关（r = 0.89）。与正常妊娠和非妊娠对照组相比，先兆子痫患者对静脉闭塞的CBV反应显著降低（p < 0.05）。这一发现表明静脉 - 小动脉反射受损，这可能导致先兆子痫中出现的水肿形成。有人提出血管舒缩活动可能作为血管阻力的生理调节因子，从而影响CBV。
