Rosén L, Ostergren J, Fagrell B, Stranden E
Vascular Research Laboratory, Aker Hospital, Oslo, Norway.
Eur J Clin Invest. 1988 Jun;18(3):305-8. doi: 10.1111/j.1365-2362.1988.tb01263.x.
Finger-skin microcirculation and its reactions to sympathetic stimuli were investigated in 12 patients with sympathetic dystrophies, secondary to trauma or other diseases. Nailfold-skin capillary blood cell velocity (CBV) was measured by videophotometric capillaroscopy. Laser Doppler fluxmetry was used to provide an index of skin circulation in vessels in addition to the superficial capillaries. Both CBV and laser Doppler flux (LDF) values were significantly lower in the patients, compared with the healthy controls (P less than 0.05), despite the fact that skin temperature was the same in both groups. During cooling of the contralateral hand, CBV and LDF decreased markedly (22-60%) in the control group but not in the patients (0-13%). The decrease in skin perfusion normally seen upon lowering of the hand was also impaired in the patient group (7%) compared with controls (42%) (P less than 0.05). These impaired vasomotor reflex responses are consistent with sympathetic dysfunction and may well explain some of the typical features of the syndrome, e.g. limb oedema.
对12例继发于创伤或其他疾病的交感神经营养不良患者的手指皮肤微循环及其对交感神经刺激的反应进行了研究。通过视频光度毛细血管镜测量甲襞皮肤毛细血管血细胞速度（CBV）。激光多普勒血流仪用于提供除浅表毛细血管外的血管皮肤循环指标。尽管两组皮肤温度相同，但患者的CBV和激光多普勒流量（LDF）值均显著低于健康对照组（P<0.05）。在对侧手冷却期间，对照组的CBV和LDF显著降低（22-60%），而患者组则无明显降低（0-13%）。与对照组（42%）相比，患者组在手部下垂时正常出现的皮肤灌注减少也受到损害（7%）（P<0.05）。这些受损的血管运动反射反应与交感神经功能障碍一致，很可能解释了该综合征的一些典型特征，如肢体水肿。
