他汀类药物反应的药物代谢组学。
Pharmacometabolomics of statin response.
机构信息
Children's Hospital Oakland Research Institute, Oakland, California, USA.
出版信息
Clin Pharmacol Ther. 2013 Nov;94(5):562-5. doi: 10.1038/clpt.2013.164. Epub 2013 Aug 14.
Abstract
Statins reduce risk of cardiovascular disease (CVD) by decreasing plasma low-density lipoprotein (LDL) concentrations, as well as reducing inflammation and improving endothelial function. Despite their documented efficacy, there is considerable interindividual variation in effects of statins on CVD biomarkers. In the studies summarized here, we used complementary metabolomics platforms to define global effects of a statin (simvastatin) on metabolism and to identify markers indicative of mechanisms that contribute to variation in plasma LDL response to statin treatment.
摘要
他汀类药物通过降低血浆低密度脂蛋白 (LDL) 浓度，以及减少炎症和改善内皮功能，降低心血管疾病 (CVD) 的风险。尽管它们的疗效已有记录，但他汀类药物对 CVD 生物标志物的影响在个体之间存在很大差异。在本文总结的研究中，我们使用互补的代谢组学平台来定义他汀类药物（辛伐他汀）对代谢的整体影响，并确定表明有助于他汀类药物治疗后血浆 LDL 反应变异机制的标志物。
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