立体选择性环化烯烃与 N-酰基半亚胺亲核试剂。
Stereoselective halocyclization of alkenes with N-acyl hemiaminal nucleophiles.
机构信息
School of Pharmacy, University of Wisconsin, Madison, Wisconsin.
出版信息
Chirality. 2013 Nov;25(11):805-9. doi: 10.1002/chir.22219. Epub 2013 Aug 15.
PMID:23946166
Abstract
Halocyclization of alkenes was realized using N-acylhemiaminal nucleophiles. High diastereoselectivity could be achieved for the formation of three stereogenic centers in this halogen-mediated cyclization reaction. We also demonstrated that enantioselective bromocyclization of alkenes using N-acylhemiaminal nucleophiles was possible.
摘要
利用 N-酰基半亚胺亲核试剂实现了烯烃的卤环化反应。在这种卤介导的环化反应中，可以实现三个立体中心形成的高非对映选择性。我们还证明了使用 N-酰基半亚胺亲核试剂对烯烃进行对映选择性溴环化反应是可行的。
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