Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10938-53. doi: 10.1002/anie.201204347. Epub 2012 Sep 25.
Despite the fact that halogenation of alkenes has been known for centuries, enantioselective variants of this reaction have only recently been developed. In the past three years, catalytic enantioselective versions of halofunctionalizations with the four common halogens have appeared and although important breakthroughs, they represent just the very beginnings of a nascent field. This Minireview provides a critical analysis of the challenges that accompany the development of general and highly enantioselective halofunctionalization reactions. Moreover, the focus herein, diverges from previous reviews of the field by identifying the various modes of catalysis and the different strategies implemented for asymmetric induction.
尽管烯键的卤化作用已经为人所知几个世纪了，但这个反应的对映选择性变体直到最近才被开发出来。在过去的三年中，带有四个常见卤素的卤官能化的催化对映选择性版本已经出现，尽管这是重要的突破，但它们仅仅代表了一个新兴领域的开端。这篇综述批判性地分析了开发通用和高对映选择性卤官能化反应所伴随的挑战。此外，本文的重点与该领域之前的综述不同，它确定了各种催化模式和用于不对称诱导的不同策略。
