College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei (P. R. China).
Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10582-5. doi: 10.1002/anie.201303911. Epub 2013 Aug 14.
C-H/C-N activation: The first palladium/copper-catalyzed aerobic oxidative C-H alkenylation/N-dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and straightforward synthesis of biologically active 3-methyleneindolin-2-one derivatives from cheap and simple substrates.
C-H/C-N 键活化：首次发展了钯/铜催化的有氧氧化条件下三级苯胺的 C-H 烯基化/N-脱烷基化羰基化反应。该反应具有很好的官能团兼容性，丙烯酸酯也可以作为合适的底物。该转化反应以廉价简单的底物为原料，高效、直接地合成了具有生物活性的 3-亚甲基吲哚啉-2-酮衍生物。
