Pliskow Steven
Department of Obstetrics and Gynecology, Palms West Hospital, Loxahatchee, Florida, USA.
J Reprod Med. 2013 Jul-Aug;58(7-8):354-6.
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a serious, drug-induced, life-threatening condition characterized by an epidermal blistering rash with necrosis, desquamation and mucosal surface involvement. This patient represents the youngest and most significant case report in the literature of gynecologic damage due to TEN.
A 31/2-year-old girl developed TEN involving 90% of her body surface area after exposure to pediatric ibuprofen. After onset of puberty she required surgery to treat vulvar, vaginal and cervical adhesions, stenosis and hematometra.
While delaying evaluation and treatment of the extremely young child with this disorder until puberty has been the standard, consideration should be given to earlier evaluation and intervention.
史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）是一种严重的、药物引起的、危及生命的疾病，其特征为伴有坏死、脱皮及黏膜表面受累的表皮水疱性皮疹。该患者是文献中因中毒性表皮坏死松解症导致妇科损伤的最年轻且最典型的病例报告。
一名3.5岁女童在接触小儿布洛芬后发生中毒性表皮坏死松解症，体表面积受累达90%。青春期开始后，她需要接受手术治疗外阴、阴道和宫颈粘连、狭窄及子宫积血。
虽然一直以来的标准做法是将患有这种疾病的幼儿的评估和治疗推迟到青春期，但应考虑更早进行评估和干预。
