Ramien Michele, Goldman Jennifer L
Department of Pediatrics, University of Calgary, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB, Canada.
Department of Medicine, University of Calgary, Calgary, AB, Canada.
F1000Res. 2020 Aug 13;9. doi: 10.12688/f1000research.20419.1. eCollection 2020.
Stevens-Johnson syndrome and toxic epidermal necrolysis are rare severe blistering skin reactions triggered by medications or infections. Over the last 5 to 10 years, a number of important publications have advanced understanding of these diseases and their response to treatment. Importantly, a subset of patients with disease triggered by infection has been identified as having Mycoplasma pneumoniae-induced rash and mucositis, suggesting a reconsideration of the diagnostic paradigm. We present an update on pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the broader context of cutaneous adverse drug reactions and focus on challenges and recent advances in diagnosis, management, and prevention.
史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症是由药物或感染引发的罕见严重水疱性皮肤反应。在过去5至10年里，一些重要出版物增进了对这些疾病及其治疗反应的认识。重要的是，已确定一部分由感染引发疾病的患者患有肺炎支原体引起的皮疹和黏膜炎症，这表明需要重新审视诊断模式。我们在更广泛的皮肤药物不良反应背景下，介绍小儿史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的最新情况，并重点关注诊断、管理和预防方面的挑战及最新进展。
