Zhang Wei-Ku, Wang Shou-Bao, Fu Cheng-Yu, Li Ping, Xu Jie-Kun
Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2013 May;38(10):1539-42.
Nine compounds were isolated and purified by column chromatographic techniques including macroporous resin, silica gel, ODS, Sephadex LH-20, and preparative reversed-phase HPLC. Their structures were elucidated as taxifolin (1), naringenin (2), chalconaringenin (3), acacetin (4), quercetin 3-O-beta-D-galactopyranoside (5), 6-prenylnaringenin (6) xanthohumol (7), desmethylxanthohumol (8), xanthohumol B (9) on the basis of MS and NMR spectroscopic data analysis. Compounds 1-5 were isolated from Humulus lupulus for the first time.
通过大孔树脂、硅胶、ODS、葡聚糖凝胶LH - 20和制备型反相高效液相色谱等柱色谱技术分离并纯化出9种化合物。基于质谱和核磁共振光谱数据分析，确定它们的结构分别为紫杉叶素（1）、柚皮素（2）、查耳酮柚皮素（3）、刺槐素（4）、槲皮素3 - O - β - D - 吡喃半乳糖苷（5）、6 - 异戊烯基柚皮素（6）、黄腐酚（7）、去甲基黄腐酚（8）、黄腐酚B（9）。化合物1 - 5首次从啤酒花中分离得到。
