Regenerative Medicine Group, Cranfield Health, Cranfield, UK.
Immun Ageing. 2013 Aug 16;10(1):34. doi: 10.1186/1742-4933-10-34.
Transfusion of autologous leukocytes after prolonged storage has been proposed as a means of rejuvenating the immune system of older individuals. The rationale for this approach is that age related immune decline is associated with a diminished pool of naïve T cells following atrophy of the thymus and reduction in thymic output. The presence of high levels of naïve T cells within the blood of young individuals could provide a boost to the immune system of an older "self" through a rejuvenation of the naïve T cell pool. However what remains unresolved is whether the cells could be incorporated effectively into the T cell pool of the host and whether effectors could be generated. Using CD45 congenic mice in our experiments we show that the transfusion of young donor cells into older congenic host animals leads to their successful incorporation into the peripheral T cell pool. When the recipients were challenged with influenza virus, specific effector CD8 cells were generated which were of both host and donor origin. We found no relationship between the number of responder cells of donor origin at the time of assay and the number of cells injected.
有人提出，输注经过长时间储存的自体白细胞可以作为一种使老年人免疫系统恢复活力的手段。这种方法的基本原理是，与年龄相关的免疫衰退与胸腺萎缩和胸腺输出减少相关联，导致幼稚 T 细胞池减少。年轻人血液中存在高水平的幼稚 T 细胞，可以通过幼稚 T 细胞池的更新为老年“自我”的免疫系统提供增强。然而，尚未解决的问题是细胞是否可以有效地整合到宿主的 T 细胞池中，以及是否可以产生效应物。在我们的实验中，使用 CD45 同基因小鼠，我们表明，将年轻供体细胞输注到老年同基因宿主动物中会导致它们成功整合到外周 T 细胞池中。当受体受到流感病毒的挑战时，会产生具有宿主和供体来源的特异性效应 CD8 细胞。我们没有发现检测时供体来源的应答细胞数量与注射细胞数量之间存在关系。
