胰腺癌中 B7-H3 表达与基质金属蛋白酶 2 表达的相关性。
Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer.
机构信息
Department of Hepatopancreatobiliary Surgery, Subei People's Hospital, Yangzhou, Jiangsu 225000, China.
出版信息
Cancer Cell Int. 2013 Aug 16;13(1):81. doi: 10.1186/1475-2867-13-81.
BACKGROUND
B7-H3 and matrix metalloproteinases 2 (MMP-2) are reported highly expressed in malignant tumor, we investigate the relationship between B7-H3 expression and MMP-2 on malignant behavior and prognosis predictable value in pancreatic cancer.
METHODS
We tested the expressions of B7-H3 and MMP-2 protein in 45 pancreatic surgical resected cancer samples; meanwhile, the clinicopathological data of enrolled patients were obtained for correlation analysis to obtain their relationship with pancreatic cancer progress.
RESULTS
The expression of B7-H3 was up-regulated with infiltrating depth, lymph node metastasis and TNM stage (P < 0.01). Positive expression rate of MMP-2 in pancreatic cancer tissues was 44.35%, whereas negative in normal pancreatic tissues. Multivariate analysis of Logistic regression showed B7-H3 and MMP-2 expressions were hazardous makers correlated with infiltrating depth (P < 0.05).
CONCLUSION
Our study showed combined detections of B7-H3 and MMP2 protein expression could identify patients at high risk in disease recurrence and prognosis more efficiently.
背景
B7-H3 和基质金属蛋白酶 2（MMP-2）在恶性肿瘤中表达较高，本研究旨在探讨胰腺癌中 B7-H3 表达与 MMP-2 之间的关系及其对恶性行为和预后预测的价值。
方法
我们检测了 45 例胰腺手术切除癌组织中 B7-H3 和 MMP-2 蛋白的表达，并同时获得了入组患者的临床病理资料，对其相关性进行分析，以获得其与胰腺癌进展的关系。
结果
B7-H3 的表达随浸润深度、淋巴结转移和 TNM 分期的增加而上调（P<0.01）。MMP-2 在胰腺癌组织中的阳性表达率为 44.35%，而在正常胰腺组织中为阴性。多因素 logistic 回归分析显示，B7-H3 和 MMP-2 的表达是与浸润深度相关的危险标志物（P<0.05）。
结论
本研究表明，联合检测 B7-H3 和 MMP2 蛋白的表达可以更有效地识别疾病复发和预后不良的高危患者。
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