Correlation between telomerase activity and matrix metalloproteinases 2 expression in gastric cancer.

OBJECTIVE

To investigate the relationship between telomerase activity (TA) and matrix metallo proteinases 2 (MMP-2) on malignant behavior and prognosis predictable value in gastric cancer.

METHODS

Telomerase activity and MMP-2 protein expressions were tested in 40 gastric surgical resected cancer samples and the clinicopathological data of enrolled patients were obtained to get correlation analysis results.

RESULTS

The expression of telomerase was up-regulated with infiltrating depth, lymph node metastasis and stage (P < 0.01). Positive expression rate of MMP-2 in gastric cancer tissues was 44.35%, negative in normal gastric tissues. Multivariate analysis of Logistic regression showed telomerase activity and MMP-2 expression were hazardous makers correlated with infiltrating depth (P < 0.05).

CONCLUSION

Combined detections of telomerase activity and MMP2 protein could identify patients at high risk in disease recurrence and prognosis more efficiently.